Clinical Trials Logo

Clinical Trial Details — Status: Withdrawn

Administrative data

NCT number NCT03143842
Other study ID # 17-47
Secondary ID
Status Withdrawn
Phase N/A
First received
Last updated
Start date April 27, 2017
Est. completion date January 25, 2022

Study information

Verified date January 2022
Source The University of Texas at Dallas
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to investigate whether it is possible to accelerate learning and improve memory performance in VNS implanted tinnitus participants by pairing VNS with a verbal paired-associate learning task.


Description:

Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory. Vagus Nerve Stimulation (VNS) has been delivered to patient populations (e.g. depression, epilepsy, …) for more than 25 years and there has been some indications that this technique has effects on cognition, more specifically memory. Studies have investigated VNS as a way to improve memory performance and it has been shown in some studies to enhance memory in rats and humans. It has also demonstrated to produce changes in the electrophysiological and metabolic profile of forebrain and brainstem structures involved in learning and memory. To investigate whether VNS can accelerate learning and improve associative memory when learning word pairs, we will investigate the performance of VNS implanted participants on a Verbal Paired-Associate memory task and compare their performance on the words that were learned while paired with VNS in contrast to their performance on the words that were learned while unpaired with VNS and in contrast to their performance on the words that were learned without VNS (i.e. 3 types/groups of words: paired with VNS, unpaired with VNS and without VNS) during the first visit and 1 day,1 week and 1 month after their first visit.


Recruitment information / eligibility

Status Withdrawn
Enrollment 0
Est. completion date January 25, 2022
Est. primary completion date April 22, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - 18-70 years old - Native English speaker Exclusion Criteria: - Acquainted with the foreign language used in the learning task

Study Design


Related Conditions & MeSH terms


Intervention

Device:
Vagus Nerve Stimulation
Delivering electrical pulses to the Vagus Nerve

Locations

Country Name City State
United States The University of Texas of Dallas Richardson Texas

Sponsors (2)

Lead Sponsor Collaborator
The University of Texas at Dallas Defense Advanced Research Projects Agency

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Associative Memory assessed by a Verbal Paired-Associate test Changes in performance in the Verbal Paired-Associate memory task is compared between three groups of learned word pairs (1) learned word pairs paired with VNS, (2) learned word pairs unpaired with VNS, (3) learned word pairs paired without VNS Baseline session and 1 day, 1 week and 1 month after the baseline session