Epiretinal Membrane Clinical Trial
Official title:
Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel.
Epiretinal membranes (ERM) are cellular membranes on the surface of the retina that result
in distortion of the vision (metamorphopsia), and decreased best-corrected visual acuity.
They are most frequently found in patients over the age of 50 and have a reported prevalence
of 7-12%. [1,2] Epiretinal membranes are caused by posterior vitreous separation, retinal
detachment, proliferative vitreoretinopathy, cataract surgery, trauma, inflammation, retinal
vascular disease, and idiopathic. [1-4] Epiretinal membrane removal by pars plana vitrectomy
combined with internal limiting membrane peeling leads to improved vision, decreased
metamorphopsia, and improved quality of life after surgery. [2] Internal limiting membrane
(ILM) peel has been associated with decreased rates of epiretinal membrane recurrence and is
also performed during vitrectomy for repair of macular holes or vitreomacular traction.
[5,6] Internal limiting membrane peeling can be performed by using an instrument to make a
break in the membrane followed by peeling with forceps, or by utilizing ILM forceps alone to
pinch and peel an unviolated ILM. No study exists comparing different intraoperative
techniques used for ILM peeling on visual outcomes and operating time. The investigators
hypothesize that using a "pinch and peel" technique will equal outcomes with shorter
operating time than other techniques.
1. McDonald HR, Johnson RN, Ai E, Jumper JM, Fu AD. Macular epiretinal membranes. Retina,
4th edition, editor Ryan SJ, Wilkinson CP, 2006, p 2509-2525.
2. Ghazi-Nouri SM, Tranos PG, Rubin GS, Adams ZC, Charteris DG. Vitrectomy and epiretinal
membrane peel surgery visual function and quality of life following. 2006;90;559-562;
Br. J. Ophthalmol
3. Haritoglu C, Gandorfer A, Gass CA, Schaumberger M, Ulbig MW, Kampik A. The Effect of
Indocyanine-Green on Functional Outcome of Macular Pucker Surgery. AM. J. Ophthal. VOL.
135,NO.3, 328-337, Mar 2003
4. Hiscott PS, Grierson I, McLeod D. Retinal pigment epithelial cells in epiretinal
membranes: an immunohistochemical study. Br. J. Ophthalmol, 1984, 68, 708-715
5. Park DW, Dugel PU, Garda J, Sipperley JO, Thach A, Sneed SR, Blaisdell J. Macular
Pucker Removal with and without Internal Limiting Membrane Peeling: Pilot Study.
Ophthalmology Volume 110, 1, Jan 2003
6. Kwok AK, Lai TY, Yuen KS. Epiretinal membrane surgery with or without internal limiting
membrane peeling. Clinical and Experimental Ophthalmology, 2005, 33:379-385
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03332758 -
Inflammasomes in Cell Death in FTMH, ERM, and RRD
|
||
Active, not recruiting |
NCT04130841 -
Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery
|
N/A | |
Recruiting |
NCT03713268 -
Intraoperative OCT Guidance of Intraocular Surgery II
|
||
Terminated |
NCT01532765 -
Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal
|
N/A | |
Completed |
NCT01474655 -
Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal
|
N/A | |
Active, not recruiting |
NCT04120311 -
Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
|
Phase 1 | |
Completed |
NCT04445142 -
Fovea ERM After Fovea-sparing ILM Peeling
|
||
Recruiting |
NCT01701518 -
A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes
|
N/A | |
Completed |
NCT01627977 -
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
|
Phase 3 | |
Completed |
NCT00408720 -
Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies
|
N/A | |
Completed |
NCT01771939 -
Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes
|
N/A | |
Completed |
NCT05171621 -
Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
|
||
Active, not recruiting |
NCT04306718 -
Cultivation of Hyalocytes From ILM and ERM Samples: a Pilot Study
|
N/A | |
Recruiting |
NCT01985490 -
Change in Foveal Avascular Zone After Removal of Epiretinal Membrane and Internal Limiting Membrane
|
N/A | |
Completed |
NCT01238393 -
Treatment of Epiretinal Membranes With Ranibizumab
|
N/A | |
Terminated |
NCT00333060 -
Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal
|
Phase 2 | |
Completed |
NCT05287269 -
Ocular Coherence Tomography During Cataract Assessment
|
||
Recruiting |
NCT05138315 -
Quantification of Metamorphopsia in Patients With Epiretinal Membranes
|
N/A | |
Recruiting |
NCT03661593 -
Aniseikonia in Epiretinal Membrane Patients
|
N/A | |
Completed |
NCT03457584 -
Effect of Air-tamponade on Intraretinal Cystoid Changes After Membrane Peeling
|
N/A |