Vitamin D Deficiency Clinical Trial
Official title:
Vitamin D Level and Risk of Infections in Cirrhotic Patients: Does it Have a Role?
It is widely known that vitamin D has an important role in calcium metabolism and bone
mineralization. Its deficiency is related to rickets and osteomalacia in children and adults
respectively. Vitamin D had a role in innate and acquired immunity. It increases innate
defense and modulates lymphocytes activation, leading to a change toward a T2 helper response
).
The role of vitamin D deficiency on the risk of bacterial infection among patients in
intensive care units has been reported. An observational studies in children reported an
association between low 25-OH vitamin D level and infectious viral diseases .
The deranged metabolism of vitamin D in liver cirrhosis was first reported in the late '70s
and was attributed mainly to impaired 25(OH)-vitamin D hydroxylation of the precursor vitamin
D caused by impaired liver function. Low level of vitamin D was found independently to be
associated with increased risk of bacterial infections in patients with liver cirrhosis.
The observed relationship between the lack of vitamin D and the increase risk of mortality in
cirrhotic patients could be attributed to bacterial infections. Thus, the association of low
vitamin D levels with liver insufficiency and infections supports the use of vitamin D as a
prognostic marker in the population of cirrhosis.
Studies on the role of vitamin D as a risk factor for infections in patients with liver
cirrhosis are not well studied in our locality(Upper Egypt).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04244474 -
Effect of Vitamin D Supplementation on Improvement of Pneumonic Children
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05459298 -
ViDES Trial (Vitamin D Extra Supplementation)
|
N/A | |
| Suspended |
NCT03652987 -
Endocrine and Menstrual Disturbances in Women With Polycystic Ovary Syndrome (PCOS)
|
||
| Completed |
NCT04476511 -
The Efficacy and the Safety of Vitamin D3 30,000 IU for Loading Dose Schedules
|
Phase 3 | |
| Completed |
NCT03920150 -
Vitamin D 24'000 IU for Oral Intermittent Supplementation
|
Phase 3 | |
| Completed |
NCT03264625 -
The Effects of Oral Vitamin D Supplementation on the Prevention of Peritoneal Dialysis-related Peritonitis
|
Phase 2 | |
| Completed |
NCT04183257 -
Effect of Escalating Oral Vitamin D Replacement on HOMA-IR in Vitamin D Deficient Type 2 Diabetics
|
Phase 4 | |
| Recruiting |
NCT05084248 -
Vitamin D Deficiency in Adults Following a Major Burn Injury
|
Phase 4 | |
| Completed |
NCT05506696 -
Vitamin D Supplementation Study
|
N/A | |
| Completed |
NCT00092066 -
A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
|
Phase 3 | |
| Completed |
NCT03234218 -
Vitamin D Levels in Liver Transplantation Recipients Prospective Observational Study
|
||
| Completed |
NCT02906319 -
Vitamin D and HbA1c Levels in Diabetic Patients With CKD
|
N/A | |
| Completed |
NCT02714361 -
A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
|
N/A | |
| Completed |
NCT03203382 -
Corneal Nerve Structure in Sjogren's
|
||
| Completed |
NCT02118129 -
Vitamin D Among Young Adults: an Intervention Study Using a Mobile 'App'.
|
N/A | |
| Completed |
NCT02275650 -
The Role of Narrowband Ultraviolet B Exposure in the Maintenance of Vitamin D Levels During Winter
|
N/A | |
| Completed |
NCT02187146 -
The Effects of Serum Vitamin D and IVF Outcome
|
N/A | |
| Not yet recruiting |
NCT01419821 -
Vitamin D and Its Affect on Growth Rates and Bone Mineral Density Until Age 5
|
N/A | |
| Completed |
NCT01651000 -
Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
|
Phase 3 | |
| Completed |
NCT01688102 -
The Effect of Oral Vitamin D Versus Narrow-Band UV-B Exposure on the Lipid Profile
|
N/A |