Visual Impairment Clinical Trial
Official title:
Treatment of Infantile and Juvenile Patients With Bardet-Biedl-Syndrome With Metformin. Evaluation of a Visual Improvement as a Side Effect of the Pediatric Treatment of Adipositas - a Prospective Pilot Study Without Control
In this prospective pilot study without control group children and young adults (10-25 years old) diagnosed with Bardet-Biedl syndrome and treated with Metformin for their adipositas will be evaluated for a possible additional effect of Metformin on visual acuity.
Within experiments with animals a positive effect of Metformin concerning the photo receptors
was shown. Several patients of the university hospital Tübingen with Bardet-Biedl-Syndrome
and Metformin therapy due to their adipositas reported a subjective improvement of the visual
acuity which was confirmed by opthalmologic tests.
This will be checked in a prospective pilot study without control group including children
and young adults (10-25 years old) diagnosed with Bardet-Biedl syndrome and treated with
Metformin for their adipositas. Therefore a possible additional effect of Metformin on visual
acuity will be evaluated under controlled conditions.
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