Vestibular Schwannoma Clinical Trial
Official title:
Whole Exome Sequencing (WES) of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data
Whole exome sequencing (WES) of 50 sporadic and 50 Neurofibromatosis Type2 (NF2)-associated vestibularis schwannomas (VS) in children and young adults. The aim is to gain insight into the complete genome of the NF2 associated VS compared to sporadic VS (control group). These data are to be correlated with the clinic, ie the auditory function (audiogram, acoustically evoked potentials) and the clinical picture as well as the tumor growth rate and general data such as sex, age, side, etc.
Whole exome sequencing (WES) of 50 sporadic and 50 Neurofibromatosis Type2 (NF2)-associated
vestibularis schwannomas (VS) in children and young adults. The aim is to gain insight into
the complete genome of the NF2 associated VS compared to sporadic VS (control group). These
data are to be correlated with the clinic, ie the auditory function (audiogram, acoustically
evoked potentials) and the clinical picture as well as the tumor growth rate and general data
such as sex, age, side, etc.
The analysis of genetic changes should provide a better insight into the oncogenesis of these
tumors. The distinct genetic characteristics between NF2-associated and sporadic VS suggest a
different oncogenesis of these tumors.
The correlation of the genetic characteristics with the partly very different clinical
appearance and a very different dynamics of the disease, in particular the tumor volume in
the course, identifies the underlying modifiers of the disease course.
Based on these genetic modifiers, patients can be stratified and individual clinical therapy
decisions can be made.
By demonstrating these genetic profiles in the peripheral blood, prospective conclusions can
be drawn about expected disease progression before intervention as well as for therapy
monitoring
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