Verticality Perception in Stroke Patients

Verticality Perception in Stroke Clinical Trial

Official title:

Verticality Perception in Patients With Acute Lateralized Lesions Along the Central Graviceptive Pathways- Acute Assessment on the Ward and the Stroke Center

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02184923
• Other study ID #: verticality_percept_stroke_zrh
• Status: Active, not recruiting
• Phase: N/A
• Start date: August 2014
• Est. completion date: December 31, 2020

Study information

• Verified date: December 2019
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright.The strategy of this research is to quantify changes in verticality perception after unilateral lesions along the central graviceptive pathways and to assess the frequency and pattern of abnormal verticality perception in patients with acute stroke (ischemic or hemorrhagic). Our underlying hypothesis is that screening for erroneous verticality perception by use of a mobile device assessing the subjective visual vertical (SVV) during the acute phase (i.e., within 24-48 hours after symptom onset) reliably identifies those patients with defects. Early detection of deficits in verticality perception may help to initiate balance physiotherapy early.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 130
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

1. ages 18-90 years

2. informed consent

3. for group 1: acute (i.e. symptom onset <3 days ago) lateralized ischemia or hemorrhage as confirmed by clinical examination and / or brain imaging (CT or MRI).

4. absence of exclusion criteria

Exclusion Criteria:

1. history of a peripheral-vestibular deficit

2. disturbed consciousness

3. severe sensory or motor aphasia

4. visual field deficits

5. other neurological or systemic disorder which can cause dementia or cognitive dysfunction

6. intake of antidepressants, sedatives, or neuroleptics

Related Conditions & MeSH terms

• Stroke
• Verticality Perception in Stroke

Intervention

Other:
• presentation of visual vertical

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich	Zurich	ZH

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

References & Publications (1)

Zwergal A, Rettinger N, Frenzel C, Dieterich M, Brandt T, Strupp M. A bucket of static vestibular function. Neurology. 2009 May 12;72(19):1689-92. doi: 10.1212/WNL.0b013e3181a55ecf. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Accuracy of verticality perception		during the measurement period (10 minutes)
Secondary	Test-re-test reliability of verticality perception		from session 1 (day 0) to session 2 (day 1)