Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery

Ventilator Lung Clinical Trial

Official title:

Comparison of Pressure and Volume Controlled Ventilation in Terms of Mechanical Power in Upper Abdominal Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05690867
• Other study ID #: 2021-2081
• Status: Completed
• Phase: N/A
• Start date: September 5, 2022
• Est. completion date: December 5, 2022

Study information

• Verified date: January 2023
• Source: Istanbul University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Comparison of mechanical powers produced at volume controlled and pressure controlled mechanical ventilation

Description:

The mechanical power created by mechanical ventilation, as a new concept, can enable to evaluate the effect of different components in the lung.Our aim in this study is to calculate mechanical power in different ventilation modes ( pressure controlled and volume controlled ventilation) and to compare them. To calculate the mechanical powers we will use Van der Meijden's mechanical power formula for pressure controlled ventilation and for volume controlled ventilation we will use Gattinoni's mechanical power formula. In the literature we haven't seen any publication comparing the mechanical power of two commonly used ventilation modes (volume controlled and pressure controlled ventilation)

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 5, 2022
• Est. primary completion date: November 5, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• ASA1-2 , >18 years old patients having upper abdominal surgery

Exclusion Criteria:

• chronic obstructive lung disease, interstitial lung disease

• chronic renal failure

• Child-Pugh > 6 liver disease

• Patients who don't give consent

• NYHA > 2 heart failure

Related Conditions & MeSH terms

• Ventilator Lung

Intervention

Other:
• Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes
group 1 starts with volume controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to pressure controlled ventilation after letting washout we take three consecutive measurements at pressure controlled ventilation and we will repeat this protocol during surgery
• Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes
group 2 starts with pressure controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to volume controlled ventilation after letting washout we take three consecutive measurements at volume controlled ventilation and we will repeat this protocol during surgery

Locations

Country	Name	City	State
Turkey	Istanbul University, Department of Anesthesiology	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul University

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x. — View Citation

van der Meijden S, Molenaar M, Somhorst P, Schoe A. Calculating mechanical power for pressure-controlled ventilation. Intensive Care Med. 2019 Oct;45(10):1495-1497. doi: 10.1007/s00134-019-05698-8. Epub 2019 Jul 29. No abstract available. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	calculation of mechanical power changes in two different ventilation modes	mechanical power will be calculated using the Van der Meijden's formula for pressure support ventilation and Gattinoni's formula for volume controlled ventilation and two mechanical powers will be compared	change from at the beginning of surgery till the end of surgery
Secondary	postoperative pulmonary complications	postoperative pulmonary complication including pneumonia, acute lung injury, respiratory failure requiring reintubation	post-operative 7 days
Secondary	hospitalisation time	up to 20 days	up to 20 days