Clinical Trials Logo

Clinical Trial Summary

Interest in low fresh gas flow anesthesia has increased in recent years. The high standard of anesthesia machines, the presence of monitors that continuously and thoroughly analyze the anesthetic gas composition, and the increased knowledge of the pharmacodynamics and pharmacokinetics of inhalation anesthetics greatly facilitated the safe administration of low-flow anesthesia.Low-flow anesthesia can be mentioned for most patients if modern re-breathing systems are used but only if the fresh gas flow rate is reduced below 2 lt / min. In 1974, Virtue was defined as a technique called minimal flow, in which the fresh gas flow was not exceeded 0.5 lt / min. Although there are too many applications for low current in the literature, there is little literature for use in one lung.


Clinical Trial Description

Our research is planned prospectively. During the preoperative examination, patients will be informed about the study and their written consent will be obtained. On the morning of the operation, anesthesia gas monitor calibration and leak test will be started with automatic tests of the anesthesia device (Drager-Perseus A500).The leak test for the ventilator and breathing circuit for the patient will be repeated in all operations. The carbon dioxide trap will be evaluated in terms of its dryness and color and will be replaced at appropriate times. The patients who were taken to the operation table were venously opened with a 20-gauge cannula from the back of the hand, and perfusion of 10 ml / kg / h 0.9% sodium chloride was started. ECG, SPO2, NIBP monitoring (Siemens SC-7700), starting before anesthesia (basal), after induction, after intubation 1.min and 5., 10., 15., 20., 25., 30., 40 ., 50th, 60th, 75th, 90th, 105th, 120th minutes and preoperative arterial blood gas (AKG) will be taken.1μg / kg fentanyl (Fentanyl Citrate, Abbott Lab. North Chicago, USA), 5-7 mg / kg thiopental (Pental) for anesthesia induction after preoxygenation in 100% O2 and fresh gas flow 4L / min with spontaneous breathing for 3 minutes with mask sodium, IE Ulagay, Istanbul, Turkey) and 0.1 mg / kg vecuronium (Norcuro, Organon, Oss. the Netherlands) was administered iv. When muscle relaxation was observed, orotracheal intubation was performed and the patient (Dräger Perseus) was adjusted with an anesthesia device to have a tidal volume of 7-10 ml / kg, respiratory frequency 12 / min, and the ratio of I: E 1: 2. The tube was placed by selective intubation with the help of fiberoptic bronchoscopy. MAC values will be kept between 4-6%. Alarm limits FiO2 30% lower limit, desflurane 10% vol upper limit, EtCO2 45mmhg upper limit Paw 5cmh20 six lower limit, 30cmh2o upper limit set. co2 absorbent, as sodalime (Sorbo-lime, Berk, Turkey) were used.

Arterial Blood Gas (ABG) analysis will be performed at zero and then half hour intervals of single lung ventilation. Special attention will be paid not to open the system. Muscle relaxant antagonism will be achieved in all patients with 0.01mg / kg of atropine and 0.03mg / kg of neostigmine. At the end of the operation, the recovery period characteristics of all patients at the 1st, 5th, and 10th minutes before and after extubation were evaluated with Aldrete Kraulik's post-anesthesia evaluation system. Gas consumption amounts will be monitored on the monitor and recorded. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04376307
Study type Interventional
Source Dr. Lutfi Kirdar Kartal Training and Research Hospital
Contact
Status Recruiting
Phase N/A
Start date May 5, 2020
Completion date September 1, 2020

See also
  Status Clinical Trial Phase
Completed NCT03909854 - Pragmatic Investigation of Volume Targeted Ventilation-1 N/A
Completed NCT05690867 - Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery N/A
Enrolling by invitation NCT06151886 - Life-dependent Home Mechanical Ventilation
Not yet recruiting NCT04229810 - Individualized Perioperative Open Lung Ventilatory Approach in Emergency Abdominal Laparotomy. A Prospective Multicenter Randomized Controlled Trial. N/A
Recruiting NCT06051188 - FCV vs PCV in Moderate to Severe ARDS N/A
Completed NCT04497090 - Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation N/A
Recruiting NCT06142474 - SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning Phase 3
Completed NCT04581642 - Nociception-Level (NOL) for the Assessment of Pain in Patient Unable to Self-Report
Recruiting NCT05134467 - Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients
Recruiting NCT05812365 - Best End-Expiratory and Driving-pressure for Individualized Flow Controlled Ventilation in Patients With COPD
Recruiting NCT04484727 - "Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"
Completed NCT03411239 - Airway Pressure Changes Using Esophageal Balloon Catheter (OBC) in Laparoscopic Surgery N/A
Recruiting NCT05116839 - Pressure Support Ventilation Versus Continuous Positive Air Way Pressure (CPAP) Using I Gelin Adult Patients, N/A
Recruiting NCT03420417 - Respiratory Mechanics in Intensive Care Patients N/A
Completed NCT04258202 - Ventilator-driven Alveolar Recruitment Maneuver N/A
Recruiting NCT04307459 - Acute Respiratory Failure and COVID-19 in Real Life
Not yet recruiting NCT05726578 - Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants N/A
Completed NCT03558620 - Effect of an Endoscopic Bite Block on Mask Ventilation N/A
Completed NCT03226925 - Mechanically-assisted Ventilation in the Treatment of Moving Tumours With Photon and Proton Therapies N/A
Not yet recruiting NCT06287632 - CPAP in Patients With Severe Obesity After Anesthesia N/A