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Vasospasm, Cerebral clinical trials

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NCT ID: NCT06443177 Not yet recruiting - Clinical trials for Aneurysmal Subarachnoid Hemorrhage

The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage

Start date: July 31, 2024
Phase: N/A
Study type: Interventional

The purpose of the study is to see that in addition to existing therapy, how well an additional procedure named spinal cord stimulation might reduce blood vessel spasm from aneurysm rupture.

NCT ID: NCT06006975 Recruiting - Ischemia Clinical Trials

Early Warning of Delayed Cerebral Ischemia

EWoDCI
Start date: September 21, 2021
Phase:
Study type: Observational

The goal of this observational study is to learn about the possibility to predict clinical course of subarachnoid hemorrhage (SAH) patients by performing the retrospective analysis of clinical data available in early pre-vasospasm phase. The main questions it aims to answer are: - What biomarkers retrieved from Computed Tomography (CT) and Computed Tomography Angiography (SAH location, leaked blood volume, cerebrospinal fluid volume, etc.) can be used to predict development of cerebral vasospasms, delayed cerebral ischemia and patients' outcome. - What biomarkers retrieved from transcranial Doppler examinations in early pre vasospasm can be used to predict development of cerebral vasospasms, delayed cerebral ischemia and patients' outcome. - What biomarkers retrieved from multimodal physiological monitoring in early pre vasospasm can be used to predict development of cerebral vasospasms, delayed cerebral ischemia and patients' outcome. - What is impact of other clinical data (blood test results, age, gender, etc.) on development of cerebral vasospasms and delayed cerebral ischemia.

NCT ID: NCT05131295 Completed - Clinical trials for Subarachnoid Hemorrhage

Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.

Start date: September 5, 2007
Phase: Phase 3
Study type: Interventional

Dapsone is a drug that has been used clinically for several decades due to its anti-infective effect, making it widely available. Its neuroprotective effects have been found through its glutamate receptors antagonistic effect. Their main objective was to study the neuroprotective properties in patients with aneurysmal subarachnoid hemorrhage and high-risk factors for the development of cerebral vasospasm. Both the placebo and the dapsone used in this clinical trial were provided by the institution's neurochemistry laboratory.

NCT ID: NCT04792944 Completed - Hydrocephalus Clinical Trials

Brain Aneurysms: Utility of Cisternal Urokinase Irrigation

BA&UK
Start date: January 1, 2007
Phase:
Study type: Observational

Despite the efforts made in its treatment, aneurysmal subarachnoid haemorrhage continues to induce high mortality and morbidity rates. Today there are treatment protocols in all hospitals. The vast majority prefer, whenever possible, the endovascular route, given its lesser aggressiveness and morbidity. Although embolization prevents aneurysm' rebleeding, it does remove the subarachnoid blood clot. Therefore, it does not modify the evolution, incidence and severity of vasospasm. The idea is to carry out a 10-year retrospective study classifying patients into five groups based on the type of treatment received, analyzing the results' differences. The aim is to improve what is done as much as possible and to be able to propose potential areas for improvement. Besides, this study will be the basis of a future prospective study, prepared without the current one's biases and errors.

NCT ID: NCT04649398 Recruiting - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration

Start date: November 25, 2020
Phase:
Study type: Observational
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NCT ID: NCT04583163 Recruiting - Stroke Clinical Trials

Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients

Start date: September 22, 2020
Phase:
Study type: Observational

This study aims to determine the inter- and intra-variability of Transcranial Doppler (TCD) ultrasound in neuro-critical care patients who are planned for consecutive daily TCD evaluations.

NCT ID: NCT04490161 Recruiting - Clinical trials for Subarachnoid Hemorrhage

Prevention of Vasospasm in SAH Through CSF Treatment

PREVAIL
Start date: January 1, 2020
Phase: N/A
Study type: Interventional
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NCT ID: NCT03377049 Completed - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm

Start date: July 28, 2019
Phase: Phase 4
Study type: Interventional

The investigators propose a technique using cone beam CT perfusion (CBCTP) imaging with an acetazolamide challenge as a potential diagnostic tool to detect a defect in cerebral autoregulation at a time when it has not yet caused clinically apparent signs or symptoms. 30 participants will be enrolled at the University of Wisconsin - Madison and can expect to be on study for about 2 weeks.

NCT ID: NCT03318783 Completed - Clinical trials for Endothelial Dysfunction

Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial

SUSHI
Start date: May 2, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH). Hypotheses: Pharmacologic inhibition of the sEH enzyme is safe and will result in increased EETs availability in the blood and cerebrospinal fluid. This study is a double-blind, placebo-controlled, phase 1b randomized trial to evaluate the safety and efficacy of GSK2256294, a novel soluble epoxide hydrolase inhibitor in patients with aneurysmal SAH.