Vasodilation Clinical Trial
Official title:
The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
In this study we aim to determine whether methotrexate influences the metabolism and
vascular effects of adenosine in humans in vivo. Adenosine is an endogenous
purine-nucleoside with potent anti-inflammatory effects. Also, adenosine receptor
stimulation induces vasodilation, ischaemic preconditioning and many other cardiovacular
effects. Previous animal studies have provided limited evidence that the anti-inflammatory
effects of methotrexate are mediated by adenosine receptor stimulation. In this study, we
aim to determine whether also in humans in vivo, methotretate influences endogenous
adenosine. Therefore, 10 patients with inflammatory arthritis are treated with methotretxae
(15 mg/week orally) for 12 weeks. Before and after treatment, vasodilation to the infusion
of adenosine and dipyridamole into the brachial artery is assessed as biomarker for the
endogenous adenosine concentration.
Also, blood is drawn for the determination of CRP, ESR, Adenosine deaminase activity adn
homocysteine.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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