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Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients

Vascular Diseases Clinical Trial

Official title:
Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant

Clinical Trial Summary

Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality. Because acid retention is common in KTRs, it is plausible that alkali therapy in KTRs may also result in improved vascular and graft function. The investigators will perform a randomized, double-blinded, placebo-controlled, 12 month study in 120 KTRs to examine the effect of sodium bicarbonate therapy on surrogate markers of CVD and graft function. The overall hypothesis is that treatment with bicarbonate will improve indicators of vascular and graft function in KTRs by decreasing complement activation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05005793
Study type Interventional
Source University of Colorado, Denver
Contact Jessica Kendrick, MD MPH
Phone 3037244837
Email jessica.kendrick@ucdenver.edu
Status Recruiting
Phase Phase 4
Start date December 1, 2021
Completion date August 31, 2026
View Details
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