Cognitive Training in Stroke Patients

Vascular Diseases Clinical Trial

Official title:

Neural Correlates and Functional Connectivity Associated With Cognitive Memory Training in Patients With Cerebral Ischemic Lesions

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03644290
• Other study ID #: Stroke Rehab
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 2, 2015
• Est. completion date: December 31, 2023

Study information

• Verified date: November 2023
• Source: São Paulo State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study aims to investigate the behavioral effects, neural correlates and functional connectivity of cognitive training in patients with stroke

Description:

The study will investigate the effects of two cognitive training strategies on behavior, neural correlates and functional connectivity of patients with vascular lesions. The first strategy is associated to the ability to apply efficient organizational semantic category strategy to a list of words. This strategy will be trained in activities similar to everyday life activities. There will be in total 5 sessions, two for measuring the generalization effects before and after training and three sessions to apply the semantic strategy in order to improve encoding and episodic memory performance. The second strategy is related to the ability to remember face-names and the strategy will involve the identification of a salient face feature, creation of a nickname and association of the nickname to the real name. There will be 5 sessions in total, two for measuring the generalization effects before and after training and three sessions to apply the face-name association strategy in order to improve encoding and episodic memory performance. These two cognitive training procedures will be carried out in two separate moments. Before and after each procedure all participants will be examined by functional MRI during resting state and during a active task using a memory encoding paradigm. The same procedure will be carried out with normal control participants.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 30
• Est. completion date: December 31, 2023
• Est. primary completion date: February 1, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• people with chronic vascular ischemic lesions (more than 6 months)

Exclusion Criteria:

• vascular hemorrhages, stenosis, psychiatric problems

Related Conditions & MeSH terms

• Vascular Diseases

Intervention

Behavioral:
• Cognitive training
Five sessions of semantic strategy training and face-name association training
• Control Condition
Five sessions of active control information and education

Locations

Country	Name	City	State
Brazil	University of Sao Paulo	São Paulo	Sao Paulo

Sponsors (2)

Lead Sponsor	Collaborator
São Paulo State University	University of Sao Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline memory performance at 6 months	Hopkins Verbal Learning Test (episodic memory test total immediate score 48 and delayed score12) and fMRI active task (news recall immediate and delayed score 12)	up to 24 weeks after intervention
Secondary	Change from baseline everyday life activity performance at 6 months	Generalization questionnaire (questions on difficulties in everyday memory total score 12)	up to 24 weeks of intervention