Vascular Diseases Clinical Trial
Official title:
Vascular Effects of Regular Cigarettes Versus electronIc Cigarette Use
The purpose of this study is to assess the effects of electronic cigarettes-nicotine and
electronic cigarette-nicotine free on endothelial function as compared to traditional
cigarettes. Due to ethical reasons, we cannot fully randomise all particpants to the three
arms.
Participants who wish to quit smoking will be randomized to
1. Switch to electronic cigarettes containing nicotine plus flavor
2. Switch to electronic cigarettes containing flavor alone Those who do not wish to quit
smoking will continue on the Tobacco Cigarette arm Treatment period will be 28 days
Electronic cigarettes (EC) are gaining popularity as an alternative to Traditional Cigarettes
(TC). Despite not containing all the harmful substances seen in TC, EC are known to contain
impurities that may have a detrimental impact on human health. The effects of ECs compared
with TC on vascular function, inflammation and oxidative stress are unknown. It is
increasingly recognised that nicotine itself has significant atherothrombotic effects.
Therefore, clinicians are unable to confidently recommend ECs as a less risky alternative to
TC.
Hypothesis: Endothelial function will be improved on EC compared to TC when measured by flow
mediated dilatation (FMD).
Potential benefit: This study will provide further information on the potential use these
devices and the risks and/or benefits associated with them, specifically in relation to
vascular health.
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