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Vascular Calcification clinical trials

View clinical trials related to Vascular Calcification.

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NCT ID: NCT02876354 Completed - Clinical trials for Vascular Calcifications

Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?

Start date: August 2016
Phase: Phase 4
Study type: Interventional

Vitamin K2 deficiency has been shown to be profound in hemodialysis patients. It is reflected by high plasma levels of dephosphorylated-undercarboxylated Matrix Gla protein (dp-ucMGP) and seems to be correlated with vascular calcifications. Vascular calcifications can be assessed using the AC24 score on a lateral abdominal X-ray. The aim of this study is to assess first the rate of decrease of dp-ucMGP in a hemodialysis cohort after supplementation with vitamin K2 and the correlation between this rate of decrease and the Aortic Calcification Severity (AC24) score. The factors associated with high levels of dp-ucMGP will be analyzed as well.

NCT ID: NCT02870829 Completed - Clinical trials for Vascular Calcification

Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K

TReVasc-HDK
Start date: July 2016
Phase: Phase 2
Study type: Interventional

The proposed study will seek to evaluate the prevalence and the progression of vascular calcification in a cohort of maintenance hemodialysis patients in Asian population. It will also evaluate the efficacy of vitamin K 2 supplementation in reducing the progression of vascular calcification in this group of patients. This will be a single-center randomized, prospective and open-label interventional clinical trial of end stage renal failure patients on hemodialysis.Primary outcome will be absolute difference in coronary artery calcium (CAC) score at 18-month between control and intervention arms. Secondary outcomes will be to compare absolute difference in aortic valve calcification, percentage of patients with regression of coronary artery calcification of at least 10%, absolute difference in aortic and systemic arterial stiffness, mortality from any cause and major adverse cardiovascular events (MACE) over the same period.

NCT ID: NCT02823093 Recruiting - Clinical trials for Vascular Calcification

Aortic Calcification and Vitamin K Antagonists

AVKAL
Start date: April 2016
Phase: N/A
Study type: Observational

The vitamin K antagonists (VKA) are necessary drugs of prevention and treatment of thrombo-embolic disease. The AVKAL study assesses the impact of VKA treatment on the aortic calcifications development. This is a biomedical research without health product, transversal and monocentric study which compares the aortic calcifications levels of two populations : one treated by VKA and the other which has never been treated by VKA.

NCT ID: NCT02719665 Completed - Osteoarthritis Clinical Trials

THE OMEGA-SPM-DOSE and OMEGA-SPM-PAD: Specialized Pro-Resolving Mediators in Patients With Peripheral Artery Disease

Start date: March 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to understand the effects of fish oil supplement (containing parts of omega-3 fatty acids) on inflammation. The investigators are aiming to identify which dose of the fish oil supplement is the most effective. The name of the fish oil supplement is "SPM Emulsion."

NCT ID: NCT02621762 Completed - Clinical trials for End Stage Renal Failure on Dialysis

Pilot Study to Investigate the Effects of Increased Dialysate Magnesium and Dialysate Bicarbonate on the Calcification Propensity of Serum

BicMag
Start date: December 2015
Phase: N/A
Study type: Interventional

The study aims to determine the effect size of magnesium and bicarbonate supplementation as a basis for future randomized controlled trials aiming at the T50-guided improvement of hard clinical endpoints in dialysis patients.

NCT ID: NCT02610933 Completed - Clinical trials for Vascular Calcification

Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients

Start date: November 2015
Phase: Phase 4
Study type: Interventional

This study examines patients on chronic hemodialysis with non-valvular atrial fibrillation, who have a CHA2DS2-VASc Score of ≥ 2 and therefore are candidates for or already receive a vitamin K antagonist. The first question is whether replacement of the vitamin K antagonist by rivaroxaban is able to slow progression of vascular calcification. The second question is whether addition of vitamin K2 to rivaroxaban can further slow down or even halt the progression of vascular calcification.

NCT ID: NCT02598635 Active, not recruiting - Clinical trials for Vitamin D Deficiency

Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis

Start date: October 2015
Phase: Phase 4
Study type: Interventional

Aim: To investigate whether cholecalciferol (4800 U/daily) or placebo for 16 weeks reduces proteins levels associated with vascular calcification (osteoprotegerin, osteopontin, osteocalcin) in patients treated with peritoneal dialysis and 25(OH) vitamin D deficiency.

NCT ID: NCT02561299 Completed - Clinical trials for Vascular Calcification

Orbital Vessel PreparaTIon to MaximIZe Dcb Efficacy in Calcified Below the Knee (BTK) Lesions - A Pilot Study

OPTIMIZE BTK
Start date: September 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to prospectively evaluate acute and long term clinical results of orbital atherectomy (OA) with adjunctive drug coated balloon (DCB) angioplasty versus DCB angioplasty alone for treatment of Peripheral Artery Disease (PAD) in below the knee (BTK) lesions.

NCT ID: NCT02542319 Completed - Clinical trials for Chronic Kidney Disease

Effect of Oral Magnesium on Vascular Calcification in Chronic Kidney Disease

MagiCal-CKD
Start date: November 2015
Phase: Phase 2
Study type: Interventional

Randomized placebo-controlled double-blinded interventional trial to investigate the effect of oral magnesium supplementation on vascular calcification in subjects with chronic kidney disease. We hypothesize that oral magnesium supplementation will reduce vascular calcification in subjects with chronic kidney disease while not decreasing bone mineral density.

NCT ID: NCT02443454 Completed - Aortic Stiffness Clinical Trials

Short and Long-term Results of Arterial Stiffness and Central Aortic Pressure After Kidney Transplantation

PWV/CP/KTx
Start date: May 2015
Phase: N/A
Study type: Observational

Central blood pressure and pulse wave velocity were measured using a Complior Analyse device in Short and Long-term after kidney transplantation.