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Vascular Brain Injury clinical trials

View clinical trials related to Vascular Brain Injury.

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NCT ID: NCT05146037 Recruiting - Stroke Clinical Trials

INTERvention With Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation (INTERCEPTavi)

INTERCEPTavi
Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The study aims to evaluate the processes of a pilot single-centre randomised controlled trial (RCT) of carbon-dioxide flushing of transcatheter aortic valves (TAVI-CO2) versus standard saline flushing of valves (TAVI-S) and assess potential neuroprotection through a number of neurological endpoints for planning of a full-sized RCT

NCT ID: NCT03886675 Recruiting - Stroke Clinical Trials

Intervention With Cerebral Embolic Protection in TEVAR: Gaseous Protection

INTERCEPT:GP
Start date: November 14, 2022
Phase: N/A
Study type: Interventional

Vascular brain infarction (VBI) occurs in 67% of patients undergoing TEVAR. Overt stroke occurs in 13% of these patients and 88% of patients suffer from neurocognitive impairment. Cerebral air embolisation during the stent-graft deployment phase of TEVAR may be a cause of VBI. Standard treatment to de-air stent-grafts is through the use of a saline flush. This study aims to investigate whether carbon-dioxide or saline is the better fluid to de-air TEVAR stent-grafts prior to insertion in to the patient and compare VBI rate in the carbon-dioxide group and saline group.