Varicose Veins Clinical Trial
Official title:
Clinical and Pathological Correlations in Chronic Venous Disease
Chronic Venous Disease (CVD) has a high prevalence in the general population of the western world. Varicose veins are the main signs of this disease that are characterized by important pathological vessel wall changes. There are also several symptoms that affect the quality of life of affected patients. The aim of this study is to correlate the main histopathological abnormalities with the type and the intensity of the symptoms.
Chronic Venous Disease (CVD) of the lower limbs is a widespread chronic condition of the
western world. There are several signs and symptoms that affect quality of life of patients
with CVD. One of the main signs of this disease are varicose veins that are enlarged,
swollen, and twisting superficial veins. Vessel wall of varicose veins shows a significant
histopathological phenotype, characterized by a distortion of structural architecture:
endothelial damage, disorganization of muscle bundles and alteration of the composition of
the extracellular matrix (ECM). Symptoms may be different, according to disease state,
progression and local inflammatory processes. To date, there is no study that correlate the
type and the intensity of symptoms with histopathological phenotype.
Aim of this study is to correlate histopathological phenotype with clinical manifestations.
A cohort of patients with varicose veins scheduled for open surgical treatment that will
undergo to stab avulsion of varicose veins will be recruited. Subsequently, venous tissue
from stab avulsion will collected in order to evaluate the following biomarkers: VEGF
(Vascular -Endothelial Growth Factor), PGP 9.5 (Protein Gene Product 9.5), Fibronectin and
Matrix Metalloproteinase- 9 (MMP-9).
VEGF has a key role as a regulator of angiogenesis; its expression is highly regulated by
hypoxia, in this case induced by venous hypertension. In addition to being a marker of
neoangiogenesis, it increases vascular permeability in inflammatory disorders. PGP 9.5 is a
marker of the innervation of the vessel wall that plays an important role in the regulation
of venous tone. Fibronectin and MMP-9 are direct markers of ECM remodeling and impairment and
they have also a role in chronic inflammation.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02441881 -
Trial of Radiofrequency Thermo-ablation Treatments of Great Saphenous Varicose Veins (3-RF Study)
|
N/A | |
| Completed |
NCT03283800 -
Copper Impact on Venous Insufficiency and Lipodermatosclerosis
|
N/A | |
| Recruiting |
NCT02676908 -
Optimum Duration of Compression Stockings After Endovenous Varicose Vein Surgery
|
N/A | |
| Withdrawn |
NCT01426035 -
Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate Cream In The Superficial Varicose Veins Treatment
|
Phase 3 | |
| Withdrawn |
NCT01203397 -
Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate In The Superficial Varicose Veins Treatment
|
Phase 3 | |
| Recruiting |
NCT02054325 -
Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins
|
Phase 4 | |
| Withdrawn |
NCT03601572 -
Hypnoanalgesia in Surgical and Endovenous Treatment of Varicosis
|
||
| Completed |
NCT04933591 -
Impact of Treatment With VENARUS® on the Level of Monocyte Chemoattractant Protein 1 in Varicose Veins Blood
|
N/A | |
| Active, not recruiting |
NCT02397226 -
Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery
|
N/A | |
| Withdrawn |
NCT02936271 -
Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting
|
N/A | |
| Terminated |
NCT02557542 -
Pilot RCT Evaluating a One Stop Vein Clinic
|
N/A | |
| Completed |
NCT00758420 -
Randomized, Single Blind, Placebo Controlled, to Evaluate Efficacy and Safety of Polidocanol Injectable Foam for Treatment of Symptomatic, Visible Varicose Veins With SFJ Incompetence
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT00841178 -
Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RCT
|
N/A | |
| Not yet recruiting |
NCT05508581 -
Microwaves Ablation of Varicose Veins
|
N/A | |
| Completed |
NCT05247333 -
Implementation of a Minor Ailment Service in Community Pharmacy Practice
|
N/A | |
| Active, not recruiting |
NCT04339075 -
Registry to Investigate the Efficacy and Safety of VenaBlock VeIn SEaling System for VaRicose Veins in SingApore
|
||
| Completed |
NCT03392753 -
Mechanochemical Ablation Compared to Cyanoacrylate Adhesive
|
N/A | |
| Recruiting |
NCT04146168 -
Lake Washington Vascular VenaSeal™ Post-Market Evaluation
|
||
| Recruiting |
NCT02304146 -
Long-term Ultrasound Guided Foam Sclerotherapy Versus Classical Surgical Stripping Study
|
N/A | |
| Completed |
NCT01200199 -
Validity of Electronic Diary for Monitoring Varicose Veins Symptoms
|