Varicose Veins Clinical Trial
Official title:
Molecular Analysis of Estrogen Receptors in Patients With Chronic Venous Disease
Chronic Venous Disease (CVD) is a very common problem affecting western adult population. To date the pathophysiology of CVD development encloses several theories such as the role of extracellular matrix (ECM) components alterations, the alteration of Matrix Metalloproteinases (MMPs) and other related molecules, the endothelial dysfunction, and several genetic factors but none of these could properly explain its genesis. Estrogen Receptors may be involved in CDV pathogenesis. Endogenous estrogens are important regulators of vascular homeostasis and they act mainly via three different ERs which are expressed in the cardiovascular system: ERα, ERβ, and a G protein-coupled estrogen receptor termed GPER. of this study is to explore the expression of estrogen receptors in vessel wall of varicose veins through the entire clinical spectrum of CVD.
Chronic Venous Disease (CVD) is a very common problem affecting western adult population
with a prevalence of < 10%, among individuals younger than 30 years for both sex, and with a
prevalence of 57% and 77%, in men and women aged ≥ 70 years respectively, and may be
frequently associated with other clinical manifestations.
The spectrum of CVD ranges from varicose veins to leg edema, and serious dermal clinical
manifestations consisting of hyperpigmentation, eczema, lipodermatosclerosis, and venous
skin ulceration.
To date the pathophysiology of CVD development encloses several theories such as the role of
extracellular matrix (ECM) components alterations, the alteration of Matrix
Metalloproteinases (MMPs) and other related molecules, the endothelial dysfunction, and
several genetic factors but none of these could properly explain its genesis.
A recent study (Serra R et al) showed a higher prevalence of CVD among patients with Breast
Cancer (BC) respect to general population, especially in those patients that were positive
to estrogen receptor (ER) expression.
The presence of ERs was investigated in the walls of normal and varicose veins by Mashiah A.
et al, previously, and they documented that increased concentrations of estrogen receptors
were found in varicose vein segments respect to healthy controls and this was particularly
evident in females.
Endogenous estrogens are important regulators of vascular homeostasis and they act mainly
via three different ERs which are expressed in the cardiovascular system: ERα, ERβ, and a G
protein-coupled estrogen receptor termed GPER.
Although ERs are also suspected to be involved in the underlying etiology, the exact
molecular mechanism responsible for development of CVD as well as the relationship with the
wide range of clinical manifestations of CVD remains to be elucidated and the aim of this
study is to explore the expression of estrogen receptors in vessel wall of varicose veins
collected from patients with varicose veins through the entire clinical spectrum of CVD.
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Observational Model: Cohort, Time Perspective: Prospective
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