Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility

Varicocele Clinical Trial

Official title:

Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters in Patients Who Underwent Surgery for Causes Other Than Infertility

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02006316
• Other study ID #: SeoulNUH
• Status: Completed
• Phase: N/A
• First received: March 17, 2010
• Last updated: May 13, 2014
• Start date: January 2000
• Est. completion date: March 2010

Study information

• Verified date: May 2014
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate whether clinical varicoceles are associated with abnormal semen parameters and whether varicocelectomy could improve the semen parameter in patients unrelated with infertility.

Description:

While most studies are continued to validate the observations of significant improvements in sperm density and motility after varicocele ligation in infertile patients, there have been few studies to investigate the effects of varicocelectomy on semen parameters in adult men unrelated with infertility. The purpose of this study was to determine whether varicocelectomy could improve the semen parameter of these patients as well as whether clinical varicoceles are associated with abnormal semen parameters in patients unrelated with infertility.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 121
• Est. completion date: March 2010
• Est. primary completion date: April 2008
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other than infertility such as testicular pain, discomfort or scrotal mass

Exclusion Criteria:

• adolescents

• men with proven fertility or azoospermia

• men with preoperative normal sperm analysis

• available data to compare between preoperative and postoperative semen analyses

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Infertility
• Varicocele

Intervention

Procedure:
• Microsurgical subinguinal varicocelectomy

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sperm concentration, motility, and morphology	To observe the change of sperm concentration, motility, and morphology pre and postoperatively in the patients of inclusion criteria	at postoperative 4months	No
Secondary	whether semen analysis should be done in men with clinical varicocele regardless of the chief complaint	this result would show the need of performing semen analysis even in the patients with clinical varicocels due to causes other than infertility	at postoperative 4months	No