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The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Vancomycin Clinical Trial

Official title:
The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level in Critically Ill Patients: A Retrospective Observational Study

Clinical Trial Summary

The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.

Clinical Trial Description

This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03806543
Study type Observational
Source Southeast University, China
Contact
Status Completed
Phase
Start date January 1, 2015
Completion date December 31, 2017
View Details
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