Valvular Disease Clinical Trial
— PRESSEVALOfficial title:
Filling Pressures of the Left Ventricle in Patients With Significant Aortic Stenosis: Study of Echocardiographic Parameters Compared to Invasive Evaluation
Left valvular heart disease has become one of the most common heart disease in Western
countries. This disease evolve over many years and are characterized by a long phase where
the patient is "asymptomatic".
it is characterized by discomfort LV filling may worsen and lead typically to a pressure
increase of LV pressure and the left atrium (LA) (1). The onset of symptoms is unpredictable
and may occur at the stage of diastolic or systolic dysfunction.
Ventricular dysfunction may be insidious, the goal is to detect early dysfunction, knowing
that it is often very difficult to know if the patient is actually symptomatic. The onset of
symptoms sign an intolerance to the increase in LV filling pressures and LA , causing
pulmonary hypertension .
Therefore, the study of the level of LV and LA filling pressures , if possible by a
noninvasive method, would identify patients apparently asymptomatic even though their
condition is advanced.
Pressures filling pressures can be explored by two methods:
- cardiac catheterization, which is a direct and invasive measurement method
- echocardiography, which is an indirect measurement method which has the advantage of
being non-invasive The goal of this research is to compare the two methods.
Status | Completed |
Enrollment | 100 |
Est. completion date | May 2014 |
Est. primary completion date | May 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Older than 18 years; - Patients hospitalized for a coarctation review, and has received or will be receiving during their stay a complete echocardiography and coronary angiography, and left and right catheterization Exclusion Criteria: - Pregnant women - Patients with a history of valve replacement surgery, - Patients with other valvular> grade 2 associated with the coarctation - Patients known to have ischemic heart disease or in whom angiography showed significant coronary artery disease; - Patients with chronic or paroxysmal atrial fibrillation - Patients with a permanently pacemaker |
Observational Model: Case-Only
Country | Name | City | State |
---|---|---|---|
France | Departement de Cardiologie | Limoges | |
France | Departement de Cardiologie | Montpellier |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Limoges |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | quality of echocardiography | Evaluate the diagnostic quality of echocardiography to measure the volume of the LA indexed to body surface area compared to cardiac catheterization | No |
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