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Vaginal Infection clinical trials

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NCT ID: NCT05109533 Completed - HPV Infection Clinical Trials

Probiotics Role in HPV Cervico-vaginal Infection Clearance

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Vaginal infections demonstrated to be implicated in the persistence of HPV, activating a vicious circle of vaginal microbial perturbations. HPV infection can destroy the biofilm barrier formed by the local vaginal immune microenvironment, leading to a condition called dysbiosis. Contemporarily, the resulting local microecological imbalance in the vagina can subsequently upregulate the expression of the HPV protein, increasing HPV-related cytological alterations.

NCT ID: NCT05044156 Completed - Candidiasis Clinical Trials

Investigation of the Relationship Between Salivary Histatine-5 Level and Vaginal Candidiasis in Women

Start date: October 21, 2021
Phase:
Study type: Observational [Patient Registry]

The low Histatine-5 (HST-5) level of the saliva can lead to vaginal candidiasis. Because HST-5 level in the saliva can effect vaginal Ph, flora and local defence mechanisms. Histatine-5 is secreted in the parotis and submandibular glands. İt riches histidine amino ascid and have antifungal activity. Salivary proteins and their plasma levels were found as similar in the literature.

NCT ID: NCT05005286 Completed - Vaginal Infection Clinical Trials

Evaluation of Breastmilk Microbiota as a Function for Immunity

Start date: December 1, 2020
Phase:
Study type: Observational

The aim of this study is to evaluate the difference of breast milk microbiota between mothers with and without vaginal infections during pregnancy.

NCT ID: NCT04461782 Completed - Vaginal Infection Clinical Trials

Interventional Study to Evaluate the Effect of the Oral Administration of L.Plantarum on Vaginal Microbiota

Start date: April 15, 2019
Phase: N/A
Study type: Interventional

Vaginal microbiota is abundantly colonized by Lactobacillus genera. When vaginal microbiota gets altered, opportunistic microorganisms may proliferate and become abundant species giving rise to dysbiosis. Probiotics are living organisms that provide the host certain benefits. Despite probiotics have been historically linked to intestinal microbiota, several research groups have published positive results for some Lactobacillus strains in vaginal microbiota. The Lactobacillus strain investigated in the presented project showed the ability to prevent recurrent vaginal Candidiasis in women with high vaginal candidiasis prevalence. Nowadays the Lactobacillus strain here investigated is commercialized as vaginal caps, however oral intake is widely preferred among consumers. Because of that, this study aims to determine whether this Lactobacillus strain is able to colonize vaginal microbiota when administered orally.

NCT ID: NCT03898726 Completed - Vaginal Infection Clinical Trials

Laparoscopic Versus Transvaginal Cuff Closure

Start date: March 27, 2018
Phase: N/A
Study type: Interventional

It is still debatable whether that the transvaginal approach to vault closure or laparoscopic suturing are associated with lower risks of vaginal cuff complications . This study aims to compare the two approaches of closure of the vaginal cuff at the end of total laparoscopic hysterectomy as regards the vaginal cuff complications .

NCT ID: NCT03372395 Completed - Vaginal Infection Clinical Trials

Probiotic Implementation as Help in Solving Vaginal Infections

Start date: February 2015
Phase: Phase 2
Study type: Interventional

Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women's well-being. The aim of the study was to confirm that vaginal Lactobacilli long-lasting implementation in women with HPVinfections and concomitant bacterial vaginosis or vaginitis might be able to help in solving the viral infection, by re-establishing the original eubiosis.

NCT ID: NCT03261804 Completed - Vaginal Infection Clinical Trials

Relation Between Internal Vaginal Douching and Vaginal Infections in Intrauterine Contraceptive Device Users

Start date: June 1, 2018
Phase:
Study type: Observational

To determine the effect of performing internal vaginal douching on the frequency and severity and type of vaginal infections in IUD users

NCT ID: NCT03050684 Completed - Vaginal Infection Clinical Trials

Does Vaginal Washing Affect the Success Rate of the Labour Induction?

Start date: February 20, 2017
Phase: N/A
Study type: Interventional

Investigators will use dinoprostone(Propess TM) for cervix ripening and labor induction in term pregnant women.Vaginal pH base is achieved with the effect of hormones in pregnancy and associated with this, vaginal infections rates increase. With the vaginal application of Propess, the preparate remains in the vagina for a long time, with controlled release,creating a film layer against bacteria and especially fungal infections and it was thought that this could be a reason for unsuccessful birth induction by preventing release of this ovule. The aim of this study is to observe whether or not the rate of caesareans with the indication of unsuccessful induction was reduced in patients by reducing the density of vaginal bacteria and fungi with vaginal lavage and thereby increasing the effect of the drug and decreasing the rate of unsuccessful inductions.

NCT ID: NCT03008421 Completed - Clinical trials for Pregnancy Complications

Oral Probiotics to Reduce Vaginal Group B Streptococcal Colonization in Late Pregnancy

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

In the present study, the investigators aim to evaluate the potential of oral probiotics, containing Lactobacillus strains, to eradicate and reduce the vaginal colonization with group B Streptococcus (GBS) during pregnancy. This could help to prevent neonatal morbidity and mortality by reducing the risk for neonatal sepsis, pneumonia, and meningitis, known as early-onset or late-onset GBS infection.

NCT ID: NCT02308046 Completed - Vaginal Infection Clinical Trials

Multi-Center Study of New Medications to Treat Vaginal Infections

SMART GIVES
Start date: June 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of terconazole gel in the treatment of vaginal infections