Probiotics Role in HPV Cervico-vaginal Infection Clearance

HPV Infection Clinical Trial

Official title: Probiotics Role in HPV Clearance When Coexisting Vaginal Infections

Status Completed

Clinical Trial Summary

Vaginal infections demonstrated to be implicated in the persistence of HPV, activating a vicious circle of vaginal microbial perturbations. HPV infection can destroy the biofilm barrier formed by the local vaginal immune microenvironment, leading to a condition called dysbiosis. Contemporarily, the resulting local microecological imbalance in the vagina can subsequently upregulate the expression of the HPV protein, increasing HPV-related cytological alterations.

Clinical Trial Description

A total of 483 women affected by different vaginal infections and concomitant HPV-positivity were enrolled between 2018 and 2020 at Department of Gynecological, Obstetrical and Urological Sciences, University "Sapienza" of Rome (Rome, Italy) and 2nd Division of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria Pisana, University of Pisa (Pisa, Italy). Women with positive swabs for infections were randomized in two groups, standard specific treatment (n=231) versus the standard treatment plus long-lasting (9 months) vaginal and oral probiotics implementation (n=252). ;

Related Conditions & MeSH terms

• Communicable Diseases
• HPV Infection
• Infections
• Papillomavirus Infections
• Vaginal Infection

• NCT number: NCT05109533
• Study type: Interventional
• Source: Azienda Ospedaliero, Universitaria Pisana
• Status: Completed
• Phase: N/A
• Start date: January 1, 2018
• Completion date: March 31, 2021