Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Uveitis Clinical Trial

Official title:

Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06070935
• Other study ID #: Nailfold capillaroscopy
• Status: Recruiting
• Start date: January 15, 2024
• Est. completion date: July 15, 2024

Study information

• Verified date: February 2024
• Source: Assiut University
• Contact: Maha Abdelrahman, PHD
• Phone: 01011212050
• Email: mahasayed[@]aun.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

Description:

The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls. The NFC parameters are: capillary density (number of capillaries per mm), dilated capillaries (apex of >20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: July 15, 2024
• Est. primary completion date: May 15, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• patients with uveitis < 18 years old

Exclusion Criteria:

• infectious uveitis
• age > 18 years old

Related Conditions & MeSH terms

• Uveitis

Locations

Country	Name	City	State
Egypt	Maha Abdelrahman	Assiut
Egypt	Maha Abdelrahman	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	capillary density by nailfold capillaroscopy	(number of capillaries per mm)	6 months
Primary	detection of number of dilated capillaries by nailfold capillaroscopy	number of dilated capillaries (apex of >20µm)	6 months
Primary	detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology	detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries	6 months
Secondary	correlation of nailfold findings with uveitis activity	correlation of capillary abnormalities detected with active uveitis.	6 months