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Clinical Trial Summary

Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05474729
Study type Interventional
Source Sun Yat-sen University
Contact Dan Liang
Phone (86)-87330402
Email liangdan@gzzoc.com
Status Recruiting
Phase Phase 1/Phase 2
Start date December 1, 2021
Completion date December 31, 2026

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