Uveitis Clinical Trial - Minocycline for Chronic Autoimmune Uveitis

Status Recruiting

Clinical Trial Summary

Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05474729
Study type	Interventional
Source	Sun Yat-sen University
Contact	Dan Liang
Phone	(86)-87330402
Email	liangdan@gzzoc.com
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	December 1, 2021
Completion date	December 31, 2026

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See also
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