Uveitis Clinical Trial
Official title:
Multicenter, Randomized, Controlled Clinical Trial Research Evaluating the Use of Combination Therapy of Glucocorticoids and Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis
This project is designed to evaluating the use of combination therapy of glucocorticoid and metformin to decrease glucocorticoid side effects in participants with autoimmune uveitis.This study also aims to evaluate the anti-inflammatory and immunosuppressive effects of combination therapy.
Status | Recruiting |
Enrollment | 138 |
Est. completion date | January 1, 2023 |
Est. primary completion date | January 1, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: 1. Attending Tianjin Medical University Eye Hospital, ophthalmology department of Peking Union Medical College Hospital, ophthalmology department of Peking University First Hospital and Zhongshan Ophthalmic Center Sun Yat-sen University from January 2018 to January 2022. 2. Chronic and non-infectious autoimmune uveitis with systemic glucocorticoids treatment (Initiation dosage = 1 mg/kg/d or = 50 mg/d). 3. FBG < 6.1 mmol/L, HbAlc<6.O%, TC <6.2 mmol/L(240 mg/d1) and TG <2.3 mmol/L(200 mg/dl). 4. All genders, age = 18 years old. 5. Ready for systemic glucocorticoids treatment. 6. Willing to follow all study requirements and sign the informed consent. 7. Without history of cancer and serious systemic diseases. Exclusion Criteria: 1. Participate in other clinical trials within the preceding one years 2. Planning ophthalmologic surgery over the next three months. 3. With other sight-threatening diseases except cataract, such as glaucoma, diabetic retinopathy, retinal detachment, and so on. 4. Taking or will take immunosuppressants which affecting glycometabolism and lipid metabolism except methotrexate,mycophenolate and azathioprine. 5. Any known history of a serious infection (e.g., HIV, hepatitis, pneumonia, syphilis or tuberculosis). 6. Any known history of diabetes mellitus, severe hepatic, renal or heart disease. 7. Any known history of drug addiction, drug abuse and malignant tumor. 8. Presence of a transplanted solid organ. 9. Pregnant women and nursing mothers. 10. Any known history of mental disorders. |
Country | Name | City | State |
---|---|---|---|
China | Tianjin Medical University Eye Hospital | Tianjin | Tianjin |
Lead Sponsor | Collaborator |
---|---|
Tianjin Medical University | Peking Union Medical College Hospital, Peking University First Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University |
China,
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The incidence of abnormal metabolic indexes | The assessments of abnormal metabolic indexes include any of these outcome measures: FBG=6.1 mmol/L, TC=6.2 mmol/L (240 mg/d1), TG=2.3 mmol/L (200 mg/dl) or BMI increased 1 kg/m^2 than before in the process of follow-up twice in a row. | 24 weeks |
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