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Methotrexate and Mycophenolate Mofetil for UVEITIS — FAST  

Uveitis Clinical Trial

Official title:
First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial

Clinical Trial Summary

In the First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial, the investigators propose to establish which immunosuppressive therapy, methotrexate or mycophenolate mofetil, is more effective as a first-line, corticosteroid-sparing agent for the treatment of non-infectious uveitis in a block-randomized, observer-masked, comparative effectiveness trial.

Clinical Trial Description

This is a randomized comparative effectiveness trial to determine which treatment, methotrexate or mycophenolate mofetil, is more effective as first-line corticosteroid-sparing treatment for patients with non-infectious intermediate, posterior and panuveitis requiring corticosteroid-sparing therapy. The primary outcome is treatment success assessed at the 6 month visit (Phase 1, 0-6 months). If patients are a treatment success, they continue on the medication for another 6 months (Phase 1, 6-12 months). Patients who are a treatment failure can crossover to the other medication (Phase 2, 0-6 months). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01829295
Study type Interventional
Source University of California, San Francisco
Contact
Status Completed
Phase Phase 3
Start date August 2013
Completion date August 9, 2018
View Details
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