Uveitis Clinical Trial
Official title:
Uveitis: Medico-economical and Clinical Evaluation of a Standardized Strategy for an Etiological Diagnosis
The Uveitis, the inflammation of the uvea, is a rare disease with an incidence of 52/100,000
inhabitants per year and a prevalence of 115 / 100,000 inhabitants per year.
The causes of uveitis are numerous and include infectious diseases, systemic and neurological
diseases, ophthalmic entities, neoplasia, and drug-related reactions. The etiological
diagnosis is important both for prognosis and therapeutics.
However, clinical evaluations to establish etiological diagnosis are not standardized. Some
authors suggest a minimalist examination, common to all kinds of uveitis. On the other hand,
others propose an evaluation guided by the anatomo-clinical type of uveitis.
We conducted a retrospective study to assess the contribution of complementary examinations
to etiological determination. In this study, we found that most patients benefited from a
wide paraclinical evaluation compared to what is usually described in the literature.
Complementary examinations were mostly systematic, without any clinical or ophthalmological
elements of orientation. This study highlighted the lack of contribution of some
examinations.
Using these results, and the literature analysis, we designed a diagnostic algorithm adapted
to the anatomo-clinical type of uveitis.
Moreover, we found that the average cost per patient was estimated at €290.51 with the
algorithm compared to €560.83 without it.
We would like to carry out a new study to estimate the efficiency as well as the
medico-economic impact of the use of a standardized strategy for the etiological diagnosis of
uveitis, compared with a free strategy.
Hypothesis:
- The standardized strategy for the diagnostic of uveitis is at least as efficient as the
free one, and costs half as much.
- The examinations prescribed, except for those from the standardized strategy, do not
contribute to etiological determination.
n/a
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