Macular Edema Clinical Trial
Official title:
Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function.
Retinal optical coherence tomography (OCT) is an established technology which enables a
detailed cross-sectional visualization of the retinal micro-anatomy, and an objective
measurement of its thickness in-vivo. Multifocal electroretinogram (MfERG) measures function
of the central retina. Both technologies are relatively new and they provide complimentary
to each other information on retinal anatomy and function.
The aims of this study is to establish normal ranges for OCT and mfERG measurements related
to age, gender and reproductive factors such as parity and the use of contraception in
Norwegians; to assess the presumably healthy central retina with the use of
anti-inflammatory medication with relation to age and sex ; to study the frequency and
extent of retinal thickening and change in retinal function in patients with anterior
uveitis not complicated with macular edema; to assess whether the presence of the HLA-B27
haplotype or uveitis recidive affects macular thickening/function in uveitis.
Normal optical coherence tomography (OCT) and Multifocal electroretinogram (MfERG)
measurements may vary with race, age, sex, parity and the use of hormone therapy in health.
It has therefore been recommended to gather normative data on the individual OCT/MfERG
equipment in each laboratory. This is the reason why we gathered our local normative
material on both machines. We also assessed our normative material on the OCT in relation to
age, sex, parity and the use of contraception for future matching with patients.
It has been hypothesized that para-inflammation states are involved in retinal aging in
health. We assume that the age-related changes we observed in our normative OCT material are
related to low-grade chronic inflammation in the retina. We therefore assessed the effect of
to commercially available anti-inflammatory eye drops- diclofenac and dexamethasone,which
are often used in inflammation-related states in ophthalmology for their effect on macular
thickness in health and with aging.
Uveitis is a frank intraocular inflammation which may lead to macular edema. Macular edema
is often transient in uveitis and its presence has been previously reported in severe or
long-lasting uveitis. In some cases mecular edema may become chronic or refractory to
treatment. However, whether uncomplicated anterior uveitis with no clinically evident
macular edema leads to macular thickening detectable with the OCT, or whether monolateral
uveitis may cause bilateral macular thickening is not known. We therefore assesed both eyes
of patients with anterior uveitis for macular thickening with the OCT.
To correlate macular anatomy with its function some subjects included in the OCT study were
also examined with the mfERG. However, at present the MfERG result have not been analyzed.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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