Uveitis Clinical Trial
Official title:
A Pilot Study to Demonstrate the Presence of Vascular Endothelial Growth Factor (VEGF) in Uveitic Cystoid Macular Edema
This study will look for the presence in blood of a substance called vascular endothelial
growth factor (VEGF) in patients with uveitis (eye inflammation). It will also look for this
substance in eye fluid samples taken from patients with uveitis who are undergoing eye
surgery.
Some patients with uveitis experience some vision loss during an inflammatory attack because
of swelling (edema) in a particular area of the retina called the macula, which is involved
in visual acuity. It may be that VEGF is involved in the development of macular edema.
Patients with uveitis who participate in this study will have about 10 cc (2 teaspoons) of
blood drawn to be examined for VEGF. They will also undergo a procedure called fluorescein
angiography to look at the blood vessels of the eye. A dye called sodium fluorescein is
injected into the blood stream through a vein. After the dye reaches the blood vessels of
the eye, photographs are taken of the retina.
In addition, patients with uveitis who are undergoing eye surgery will have a tissue
specimen (either aqueous fluid or vitreous gel) collected for examination for the presence
of VEGF.
Status | Completed |
Enrollment | 60 |
Est. completion date | June 2000 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
For Uveitis Patients: Evidence on ocular examination in the past or presently of intraocular inflammation, with cells and haze in the vitreous for the intermediate and posterior uveitis patients. In order to demonstrate the presence or absence of macular edema, a fluorescein angiogram will be attempted on all patients. However, if the patient is unable or not willing to undergo the test, then if two observers from the LI can substantiate independently that there is or is not evidence of cystoid edema, the patient may be included. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Eye Institute (NEI) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Eye Institute (NEI) |
United States,
Nussenblatt RB, Kaufman SC, Palestine AG, Davis MD, Ferris FL 3rd. Macular thickening and visual acuity. Measurement in patients with cystoid macular edema. Ophthalmology. 1987 Sep;94(9):1134-9. — View Citation
Nussenblatt RB. Proctor Lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest Ophthalmol Vis Sci. 1991 Dec;32(13):3131-41. Review. — View Citation
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