Uveitis Clinical Trial
Official title:
A Pilot Study to Demonstrate the Presence of Vascular Endothelial Growth Factor (VEGF) in Uveitic Cystoid Macular Edema
This study will look for the presence in blood of a substance called vascular endothelial
growth factor (VEGF) in patients with uveitis (eye inflammation). It will also look for this
substance in eye fluid samples taken from patients with uveitis who are undergoing eye
surgery.
Some patients with uveitis experience some vision loss during an inflammatory attack because
of swelling (edema) in a particular area of the retina called the macula, which is involved
in visual acuity. It may be that VEGF is involved in the development of macular edema.
Patients with uveitis who participate in this study will have about 10 cc (2 teaspoons) of
blood drawn to be examined for VEGF. They will also undergo a procedure called fluorescein
angiography to look at the blood vessels of the eye. A dye called sodium fluorescein is
injected into the blood stream through a vein. After the dye reaches the blood vessels of
the eye, photographs are taken of the retina.
In addition, patients with uveitis who are undergoing eye surgery will have a tissue
specimen (either aqueous fluid or vitreous gel) collected for examination for the presence
of VEGF.
Increased intraocular and systemic levels of the angiogenic factor vascular endothelial growth factor (VEGF) is associated with new vessel growth in the eye, such as diabetic retinopathy. Recent work using immunopathologic techniques have shown that VEGF is upregulated in both experimentally induced uveitis and in uveitic eyes as well, with no evidence of neovascularization. This pilot study will evaluate the level of VEGF in the blood of uveitic patients with and without macular edema. This level will be determined also in the ocular fluid of those patients that are undergoing ocular surgery. These levels will be compared with age and sex matched controls. ;
N/A
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