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Uveitis clinical trials

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NCT ID: NCT04183387 Completed - Uveitis Clinical Trials

Simvastatin in Uveitis

Start date: September 2014
Phase: Phase 2
Study type: Interventional

The study evaluates anti-inflammatory effects and safety of simvastatin in non-infectious uveitis.

NCT ID: NCT04148365 Completed - Uveitis Clinical Trials

Medication Compliance in the Paediatric Uveitis Population Reported by the Patients and Parents

Start date: February 14, 2020
Phase:
Study type: Observational

Little is known about eye drop regime adherence in the paediatric population. In particular, no previous research has investigated this in the paediatric uveitis population, a group who can require doses up to six times daily, and at frequencies that change month to month. The aim of the study is to quantify the range of adherence to eye drop medication, and to investigate some of the reasons for non-compliance in a child specific study. By learning more about compliance, this will help create treatments that are better suited to children. The study will recruit 50 children receiving eye drop treatment. After an interval of 1 week or more the children and their parents will be asked to complete a questionnaire about the frequency of the drops prescribed, and the frequency that they have used over the last interval. It will also ask questions about difficulties encountered administering the drops. Changes in eye drop bottle weight will be measured during the interval and the result compared. The information gathered from the questionnaires will be used to compare reports of adherence between the parent and child, the child's age and the bottle weight. The reasons reported for difficulties with adherence will also be reported. This is a preliminary investigatory study to identify whether an issue with medication non-adherence exists. The findings will be used to tailor further research into this area.

NCT ID: NCT04018599 Completed - Clinical trials for Rheumatoid Arthritis

Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS

Start date: July 15, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to demonstrate equivalence of the pharmacokinetic (PK) profile of MSB11022 administered by either an auto-injector (AI) or a pre-filled syringe (PFS) as single subcutaneous (s.c.) injection of 40 mg.

NCT ID: NCT03971279 Completed - Posterior Uveitis Clinical Trials

Dexamethasone Intravitreal Implant (Ozurdex®) for Recurrent Vogt-Koyanagi-Harada (VKH) Disease Posterior Uveitis

Start date: January 1, 2017
Phase:
Study type: Observational

VKH disease is a vision threatening condition.The investigators consider that ozurdex intravitreal implant is an effective line of treatment in recurrent VKH posterior uveitis.

NCT ID: NCT03941184 Completed - Clinical trials for Rheumatoid Arthritis

Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Start date: January 1, 1995
Phase:
Study type: Observational

This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.

NCT ID: NCT03899922 Completed - Uveitis Clinical Trials

Monitoring Drug-induced Uveitis

UVETOX
Start date: April 1, 2019
Phase:
Study type: Observational

Several drugs and chemotherapies seem to induce uveitis. This study investigates reports of uveitis, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).

NCT ID: NCT03871361 Completed - Uveitis Clinical Trials

Abatacept in Patients With Birdshot HLA A29 Uveitis

HLA-A29
Start date: April 1, 2019
Phase: Phase 2
Study type: Interventional

To assess the efficacy and safety of Abatacept as an immunosuppressive treatment in Birdshot uveitis. The primary objective is to test the efficacy to suppress inflammation in active Birdshot uveitis patients, using quantitative and qualitative measurements of visual function.

NCT ID: NCT03753893 Completed - Macular Edema Clinical Trials

Ocular Manifestations in Rheumatic Diseases

Start date: May 1, 2013
Phase:
Study type: Observational

This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.

NCT ID: NCT03646890 Completed - Uveitis Clinical Trials

Epidemiology and Clinical Features of Uveitis in a Tertiary Referral

Start date: January 1, 2002
Phase:
Study type: Observational

The aim of the study is to report the pattern of uveitis in patients attending a tertiary referral center at the University hospital in Montpellier. The patients seen at the specialized consultation for uveitis between 2002 and first semester 2018 were included. Data about demography, clinical features and final diagnoses were collected and updated during the differenet visits. The medical records were restrospectively rewieved and analyzed.

NCT ID: NCT03598452 Completed - Infection Viral Clinical Trials

High-dose Intravitreal Injection of Ganciclovir for the Treatment of CMVR in HIV-negative Patients

Start date: January 2014
Phase: N/A
Study type: Interventional

This prospective, non-randomized, non-controlled clinical trial was conducted to examine the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections of ganciclovir in treating cytomegalovirus (CMV) retinitis in patients without human immunodeficiency virus (HIV) infection.