Urothelial Carcinoma Clinical Trial
Official title:
The Effectiveness and Safety of Intravesical Docetaxel Instillation After Operation to Prevent Intravesical Recurrence After Radical Nephroureterectomy or Distal Ureterectomy in Upper Urinary Tract Urothelial Carcinoma: A Prospective Study
The investigators evaluated the efficacy of a single early intravesical instillation of doxetaxel in the prevention of bladder recurrence after nephroureterectomy or distal ureterectomy for upper urinary tract urothelial carcinoma (UUT-UC).
Approximately 20% to 50% of patients with upper urinary tract urothelial carcinoma (UUT-UC)
experience bladder recurrence after nephroureterectomy. Although many agents have been
administered for the prevention of bladder recurrence, the standard prophylactic treatment
has yet to be established. A meta-analysis found that a single instillation of chemotherapy
immediately after transurethral resection of bladder tumor (TURBT) significantly decreased
the risk of recurrence in patients with bladder cancer. Indeed, a single early instillation
of Docetaxel was found to reduce the post-TURBT bladder recurrence rate among patients with
bladder cancer.
In this prospective, randomized study, the investigators evaluated the efficacy of a single,
early, intravesical instillation of Docetaxel in the prevention of bladder recurrence after
nephroureterectomy for UUT-UC.
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