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Urolithiasis clinical trials

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NCT ID: NCT04506723 Recruiting - Urolithiasis Clinical Trials

Comparison of Morphological and Radiological Data in Patients With Urolithiasis

Start date: April 30, 2020
Phase: N/A
Study type: Interventional

The aim of the study was to compare the ultrastructural changes in the renal parenchyma with the results of postprocessing CT analysis with contrast enhancement in patients with urolithiasis.

NCT ID: NCT04346485 Recruiting - Urolithiasis Clinical Trials

Comparison of SP TFL and Ho:YAG for RIRS Using 145 µm and 200 µm Fibers

Start date: March 13, 2020
Phase: N/A
Study type: Interventional

The authors hypothesize that the RIRS using 150-microm Tm-fiber laser is superior than fiber with larger diameters, as 200-microm Tm-fiber laser or 200-microm holmium fiber laser, in such points as follows: - decreasing surgery time and laser-on time due to possibility of 4.3 fold ablation efficacy increase, which has been shown by Andreeva et al.; - increasing the flexible ureteroscope tip deflection lower pole stones availability; - decreased risk of complications and a better irrigation and visualization due to better irrigation with smaller fiber; - increasing of lithotripsy efficacy and laser beam density by lowering of beam focal spot due to using of lesser fiber diameter

NCT ID: NCT04284241 Recruiting - Urolithiasis Clinical Trials

Parents' Health-Education Handbook in Preventing Pediatric Urolithiasis Formation

Start date: November 20, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to estimate the role of Parents' Health-Education Handbook in preventing pediatric urolithiasis. This study is designed as an unmatched clusters randomized intervention trial. A total of 171 villages and communities in Shufu Count in Kashgar Region of China are assigned to intervention group or control group by a simple random sampling technique with a rate of 1:1. Newborns and their parents are assigned to intervention group or control group as their villages or communities. And at least 2314 newborns are needed in this study. Participants include newborns and their parents. The baseline of newborns includes demographic data, blood cell analysis, urinary tract ultrasonographic examination. Newborns' parents will be asked to answer a questionnaire which regarding the knowledge, attitudes, and practices (KAP questionnaire, estimated by scores) related to pediatric stone. Parents in intervention group will undergo and active health education by the investigator with " Parents' Health-Education Handbook", while parents in control group are without the program. Newborns are invited to undergo blood cell analysis, urine analysis and urinary tract ultrasonographic examination separately when they are one, two and three years old. Their parents will be asked to answer the same KAP questionnaire at the same time. The incidence of urolithiasis is evaluated and compared between the two groups. Improvement of knowledge, attitudes, and practices (KAP questionnaire) related to pediatric stone of parents are evaluated. Association between urolithiasis incidence and improvement of scores in KAP questionnaire are evaluated.

NCT ID: NCT04069013 Recruiting - Kidney Diseases Clinical Trials

Standard vs Mini-PCNL for the Treatment of Stone Disease

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Randomized comparison of patient outcomes following standard PCNL versus mini-PCNL.

NCT ID: NCT04021381 Recruiting - Urolithiasis Clinical Trials

Citrate Salts for Stone-free Result After Flexible Ureterorenoscopy for Inferior Calyx Calculi

CiRUS
Start date: September 25, 2020
Phase: Phase 3
Study type: Interventional

The prevalence of urolithiasis is around 10 % in the French population. It is thus a major public health issue. When the stone is not spontaneously removed, interventions such as extracorporeal lithotripsy or flexible ureteroscopy (F-URS) are performed. F-URS is usually preferred in renal stones > 7 mm in comparison with lithotripsy, with better results. Efficacy of ureteroscopy is based on the "stone-free rate" (SFR) at 3 months. A SFR index is assessed according to the existence of residual fragments and their size. SFR score 1 (fragment ≤ 1mm) has been poorly studied, and is supposed to occur in 60% of cases. These residual fragments account for the high frequency of recurrence, probably favored by crystals aggregation and growth of these fragments under supersaturated urines. Indeed, calcium stones risk factors are urine supersaturation and crystal growth inhibitors deficiency. Citrate is the major crystal growth inhibitor in human urine. A hypocitraturia is reported in half of the lithiasic population. Consequently, citrate salts appear as an interesting therapeutic option, in order to slow crystal growth but also to chelate calcium, and consequently to solubilize stones in situ. However, to date, there is no available controlled study after surgical intervention such as flexible ureteroscopy. The aim of the investigator's study is to evaluate the efficacy of a 3-month potassium and magnesium citrate treatment following ureteroscopy on the elimination of residual fragments (SFR score 1).

NCT ID: NCT03919227 Recruiting - Urolithiasis Clinical Trials

Measurement of Resistance During UAS Insertion Procedure in RIRS

Start date: September 12, 2018
Phase: N/A
Study type: Interventional

Retrograde intrarenal surgery (RIRS) has been considered as the first-line choice for the management of <20mm kidney stones. Insertion of a ureteral access sheath (UAS) before RIRS surgery is currently accepted as an effective method to improve the effectiveness of surgery, but can be accompanied by serious complications. In long-term clinical practice, the investigators has found that different Bladder Filling Degree was accompanied by different Resistance During UAS Insertion Procedure in RIRS, which leads to the difference in success rate of UAS insertion.The investigator aims to perform a prospective and randomized controlled trial comparing the success rate of UAS insertion procedure under different bladder filling degree,and discuss the relationship between insertion resistance and ureter injury.

NCT ID: NCT03846011 Recruiting - Urolithiasis Clinical Trials

Comparison of 24-hour Collecting Urine Prior and After Stone Removal

Start date: March 1, 2019
Phase:
Study type: Observational

The metabolic evaluation is crucial for determining possible underlying diseases causing stone growth and to consider the lifestyle changes or medical prophylaxis needed to prevent or at least reduce stone recurrence. 24-hour urine collection is the main part of the metabolic evaluation. The time point is suggested between 3 weeks and 3 month after stone removal, but so far there are no studies comparing 24-hour urine prior and after stone removal. In this study, investigators would like to analyze parameters in the 24-hour urine prior and after complete stone removal to see whether metabolic status can be evaluated no matter stone free or not.

NCT ID: NCT03717285 Recruiting - Urolithiasis Clinical Trials

Under Direct Vision vs Under Non Direct Vision of Insertion of UAS in RIRS

Start date: September 10, 2018
Phase: N/A
Study type: Interventional

Retrograde intrarenal surgery (RIRS) has been considered as the first-line choice for the management of <20mm kidney stones. Insertion of a ureteral access sheath (UAS) before RIRS surgery is currently accepted as an effective method to improve the effectiveness of surgery, but can be accompanied by serious complications. In long-term clinical practice, the investigators has found that many ureteral injuries occur during UAS insertion of the ureter from ureteral orifice. And if we use rigid ureteroscopy to insert the UAS under direct vision, we can provide the placement success rate and reduce the incidence of complications. The investigator aims to perform a prospective and randomized controlled trial comparing the safety and efficacy of under direct vision and under non direct vision during the insertion of UAS.

NCT ID: NCT03307096 Recruiting - Clinical trials for Surgery--Complications

Evaluation of Two Different Treatments for Lower Pore Renal Stone: Microperc Vs FURS

Start date: November 17, 2017
Phase: N/A
Study type: Interventional

This is a prospect, randomized control trial to evaluate merits between microperc and FURS for lower pole renal stone

NCT ID: NCT03207659 Recruiting - Urolithiasis Clinical Trials

Dusting vs Basketing in RIRS: a Single-center Prospective Randomised Trial

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

The investigator aims to perform a prospective and randomized controlled trial comparing the safety and efficacy of active basket extraction of fragments and stone dusting during the RIRS.