Urinary Tract Infections Clinical Trial
Official title:
Urinary Tract Infection Due to Extended-spectrum Beta-lactamase-producing Enterobacteriaceae in Children: an Observational French Study
Urinary tract infection due to Extended-spectrum beta-lactamase producing enterobacteriaceae
(E-ESBL UTI) become a frequent problem. A too large variety in the prescription of
antibiotics for E-ESBL UTI in children and absolute recommendations regarding the optimal
treatment of E-ESBL is nearly impossible at this time.
Our aim was to describe the characteristics and treatments of urinary tract infections caused
by Extended spectrum betalactamase-producing Enterobacteriaceae in children.
In this prospective observational study between March 2013 and March 2017, children (0 to 18 years) with ESBL-E UTI were enrolled in 24 pediatric departments in France. Clinical and biological characteristics, risk factors of infection of E-ESBL, first and second lines of antibiotic therapies were analyzed. The investigators used the Kaplan-Meier method to estimate the time to fever defervescence and hospitalization duration, and Log-rank test to assess equality of survivor functions. The investigators also analyzed the resistance patterns and molecular characterization of ESBL types in the isolates. ;
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