Intervention Study to Improve Antibiotic Prescription in Outpatient Care

Urinary Tract Infections Clinical Trial

— SAPI  

Official title:

Improvement of Antibiotic Prescription in Outpatient Care: a Cluster-randomised Intervention Study Using a Sentinel Surveillance Network of Physicians

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01358916
• Other study ID #: Swiss Federal Office of Health
• Status: Completed
• Phase: N/A
• First received: May 19, 2011
• Last updated: March 27, 2013
• Start date: November 2010
• Est. completion date: December 2012

Study information

• Verified date: March 2013
• Source: University of Bern
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Federal Office of Public Health (Bundesamt fuer Gesundheit)
• Study type: Interventional

Clinical Trial Summary

Antimicrobial resistance has become a world-wide problem and antibiotic consumption is a major driving force for the development of resistance. Thus optimization of antibiotic prescription and reduction of unnecessary antimicrobial treatment are essential in the prevention and reduction of antimicrobial resistance rates.

The goal of this study is the improvement of antibiotic prescription in outpatient care. The study will take place within a Swiss-wide sentinel surveillance network of physicians. The participating physicians will be randomised in a control and intervention group. The intervention group will receive therapeutic guidelines for the treatment of upper and lower respiratory tract infections and lower urinary tract infection as well as regular feed-backs on the prescription pattern of the sentinel physicians during the past months. Sentinel physicians will collect information about each antibiotic prescription, its indication and characteristics of the patient.

Our hypothesis is that the prescription pattern in the intervention group will be optimised and unnecessary antibiotic therapy will be reduced compared to the control group.

Description:

Background

Antimicrobial resistance has become a world-wide problem and antibiotic consumption is a major driving force for the development of resistance. Thus optimization of antibiotic prescription and reduction of unnecessary antimicrobial treatment are essential in the prevention and reduction of antimicrobial resistance rates.

The goal of this study is the qualitative and quantitative improvement of antibiotic prescription in outpatient care. The study will take place within a Swiss-wide sentinel surveillance network consisting of general practitioners, pediatricians and physicians specialized in internal medicine. The participating physicians will be randomised in a control and intervention group. The intervention group will receive therapeutic guidelines for the treatment of upper and lower respiratory tract infections and lower urinary tract infections. Furthermore, regular feed-backs on the prescription pattern of the sentinel physicians in the last months will be provided.

Information about each antibiotic prescription, its indication and the characteristics of the patients will be collected by the sentinel physicians. The standardized reporting of antibiotic prescription by sentinel physicians has been carried out in Switzerland since 2006.

Our hypothesis is that the intervention will affect the antibiotic prescription pattern and that the investigators will observe an optimization of antibiotic prescription and a decrease in the number of antibiotic prescriptions.

Objective

Primary goals:

• Increase of the percentage of penicillin prescriptions for upper and lower respiratory tract infections

• Increase of the percentage of TMP/SMX prescriptions for lower urinary tract infections in adults

Secondary goal:

• Decrease of the percentage of quinolone prescriptions for COPD exacerbations in adults

• Decrease of the number of antibiotic prescriptions for sinusitis and other upper respiratory tract infections

Methods

Prospective cluster-randomised intervention study. The intervention is the mailing of treatment guidelines for upper and lower respiratory tract infections and lower urinary tract infections as well as regular feed-backs on the antibiotic prescription patterns of the sentinel physicians during the past months.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 140
• Est. completion date: December 2012
• Est. primary completion date: December 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients with respiratory tract infections or urinary tract infections

Exclusion Criteria

• Patients with chronic disease requiring regular antibiotic treatment

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Infection
• Respiratory Tract Infections
• Urinary Tract Infections

Intervention

Other:
• Mailing of antibiotic therapy guidelines to the sentinel physicians
Mailing of antibiotic therapy guidelines to the sentinel physicians and regular feedback on antibiotic prescription

Locations

Country	Name	City	State
Switzerland	Institute for Infectious Diseases	Bern

Sponsors (5)

Lead Sponsor	Collaborator
University of Bern	Bundesamt für Gesundheit, Pädiatrische Infektiologie Gruppe Schweiz, Schweizerische Gesellschaft für Infektiologie, Sentinella Netzwerk

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of prescriptions of penicillin for respiratory tract infections		Two years	No
Primary	Percentage of prescriptions of TMP/SMX for lower urinary tract infections in adults		Two years	No
Secondary	Percentage of prescriptions of quinolone for COPD exacerbations in adults		Two years	No
Secondary	Percentage of antibiotic prescriptions for the indications "sinusitis" and "other upper respiratory tract infections"		Two years	No