Urinary Tract Infections Clinical Trial
Official title:
Clinical Significance and Optimal Treatment of Community-onset Urinary Tract Infections Caused by Extended-spectrum β-lactamase and/or AmpC β-lactamase Producing Enterobacteriaceae
The purposes of this study are:
1. To estimate the prevalence of extended spectrum β-lactamase (ESBL) and/or AmpC among
Enterobacteriaceae which cause community-onset urinary tract infections (UTIs)
2. To collect the background, risk factors and clinical outcome of patients with
community-acquired uropathogenic condition related to Enterobacteriaceae (both ESBL,
AmpC- and non ESBL and/or AmpC producing) after receive different antibiotic regimens.
3. To develop a scoring system to early identify patients at risk of being infected with
ESBL- and/or AmpC-producing Enterobacteriaceae by comparing the risk factors for
community-onset UTIs caused by ESBL- and/or AmpC-positive against non ESBL -and/or AmpC
Enterobacteriaceae
4. To demonstrate the efficacy and safety of ertapenem for the empiric treatment of
community-onset UTIs in patients at risk for ESBL- and/or AmpC-producing organism.
The study hypothesis (i) Patients infected with community-acquired uropathogenic ESBL-
and/or AmpC-producing Enterobacteriaceae who receive regimens other than carbapenems have a
worse outcome.
(ii) There are certain risk factors predicting the acquisition of community-onset UTIs
caused by ESBL- and/or AmpC-producing Enterobacteriaceae.
(iii) The use of ertapenem is an effective and safe empirical therapy compared with other
agents for community-onset UTIs caused by ESBL- and/or AmpC-producing Enterobacteriaceae.
n/a
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