Urinary Tract Infection Clinical Trial
Official title:
The Role of TLR-4 Asp299Gly and Thr399Ile Polymorphisms in Children With Urinary Tack Infections
Purpose So far anatomical abnormalities (mostly congenital) were, in the majority of the
patients, associated with urinary track infections. In this study the researchers will try
to investigate the role of TLRs as molecular interactions between bacterial virulence and
host response.
TLRs are important mediators in the development of the natural immunity against bacteria.
They recognize microbial pathogen associated molecular patterns and alert the host's immune
system to the presence of invading microbes
The aim of his observational case-control study is to :
1. investigate if the expression of TLR2 and TLR4 mediate in the development of the
natural immunity of the uroepithileal cells against bacteria.
2. evaluate the effect of the TLR-gene Asp299Gly and Thr399Ile polymorphisms on the
development and clinical severity of urinary tract infections (UTI) in children.
3. determine the association of the expression of TLR-2 and TLR-4 and TLR-4 polymorphisms
with the formation of renal scar in children.
4. investigate the expression of TLR-2 and TLR-4 and TLR-4 polymorphisms in healthy
children and elaborate the results to the possible carriers of these polymorphisms.
;
Observational Model: Case Control, Time Perspective: Prospective
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