Pneumonia Clinical Trial
Official title:
Albumin Administration in the Prevention of Hepatorenal Syndrome and Death in Patients With Cirrhosis, Bacterial Infections Other Than Spontaneous Bacterial Peritonitis and High Risk of Hospital Mortality
The aim of this study is to evaluate whether albumin administration improves short-term survival in patients with advanced cirrhosis and bacterial infections other than Spontaneous Bacterial Peritonitis (SBP).
The aim of this study is to evaluate if IV albumin administration improves short-term
survival in patients with advanced cirrhosis (serum creatinine ≥ 1.2 mg/dl, serum sodium ≤
130 mEq/l -milliequivalents per liter- and/or serum bilirubin ≥4 mg/dl) and bacterial
infections other than spontaneous bacterial peritonitis (urinary infection, pneumonia,
spontaneous or secondary bacteremia, skin/soft tissue infection, acute cholangitis or
suspected bacterial infection).
Primary goals of the study:
• Effect of albumin administration on hospital survival
Secondary goals of the study:
- Effect of albumin administration on 28-day and 90-day survival.
- Effect of albumin administration on the incidence of renal dysfunction, AKI, type-1 and
2 Hepatorenal Syndrome (HRS) during hospitalization.
- Effect of albumin on circulatory function estimated by changes in plasma levels of
renin and noradrenaline and in serum levels of lactate among infection diagnosis, day 3
and infection resolution.
- Effect of albumin on serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha
(TNF-alpha) and nitric oxide (NOX) and on plasma levels of von Willebrand factor
(vWF:Ag) at diagnosis and resolution of infection.
- Effect of albumin on blood leukocyte count and serum C-reactive protein levels (CRP)
during infection.
- Effect of albumin on the development of other individual organ failures (renal, liver,
cerebral, circulatory, coagulation and respiratory), acute-on-chronic liver failure
(ACLF type 1, 2 and 3 according to the Canonic Study), CLIF-SOFA score, CLIF-Consortium
score, Child-Pugh score and MELD score during hospitalization.
- Evaluation of predictive factors of HRS and ACLF development in non-SBP infections.
- Samples (blood, plasma, serum and urine) will be obtained and stored for genomic,
proteomic and standard biochemical investigations in future ancillary studies related
to the aim of the study.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04244474 -
Effect of Vitamin D Supplementation on Improvement of Pneumonic Children
|
Phase 1/Phase 2 | |
Completed |
NCT05815264 -
Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Chinese Population Aged 2 Years and Above
|
Phase 1 | |
Recruiting |
NCT04589936 -
Prone Position to Improve Oxygenation in COVID-19 Patients Outside Critical Care
|
N/A | |
Completed |
NCT02905383 -
The Effect of Exercise on Physical Function and Health in Older People After Discharge From Hospital
|
N/A | |
Terminated |
NCT03944551 -
Bubble Continuous Positive Airway Pressure for Children With Severe Pneumonia in Mali, Africa
|
N/A | |
Completed |
NCT06210737 -
A Study to Evaluate Persistence of Immunity of PCV13 in Healthy Population Aged 2 Months,7 Months-5 Years
|
Phase 4 | |
Terminated |
NCT04660084 -
Impact of Molecular Testing on Improved Diagnosis, Treatment and Management of CAP
|
N/A | |
Not yet recruiting |
NCT05649891 -
Checklists Resuscitation Emergency Department
|
N/A | |
Withdrawn |
NCT05702788 -
Efficacy and Safety of Jaktinib in Participants With Severe Novel Coronavirus Pneumonia(COVID-19)
|
Phase 2 | |
Not yet recruiting |
NCT04171674 -
Pharmacokinetics of High-dose Ceftobiprole in Community-acquired Pneumonia Under Mechanical Ventilation.
|
N/A | |
Active, not recruiting |
NCT03140163 -
Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT [ULD-CT] and Conventional Chest Radiography [CXR]
|
N/A | |
Completed |
NCT02638649 -
Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
|
||
Completed |
NCT02864420 -
Hospitalization at Home: The Acute Care Home Hospital Program for Adults
|
N/A | |
Recruiting |
NCT02515565 -
Physiotherapy in Patients Hospitalized Due to Pneumonia.
|
N/A | |
Completed |
NCT02105298 -
Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)
|
N/A | |
Completed |
NCT01399723 -
Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia
|
Phase 3 | |
Completed |
NCT01446926 -
Study of Investigational Pneumococcal Vaccine in Healthy Adults, Toddlers and Infants
|
Phase 1 | |
Completed |
NCT01416519 -
Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation
|
N/A | |
Completed |
NCT01416506 -
Community-Acquired Pneumonia (CAP) Surveillance
|
N/A | |
Completed |
NCT01476995 -
Prognostic Indicators as Provided by the EPIC ClearView
|
N/A |