Urinary Calculi Clinical Trial
Official title:
Urinary Proteomic Profiling Using ProteinChip SELDI-TOF-MS: A Potential Means of Identifying Protein Biomarkers of Urinary Stone Formers
Urinary protein levels are not routinely measured in stone patients while there is strong evidence that proteins play a role in the etiology of stones. The purpose of this study is to examine the urinary and serum proteins of stone formers compared to healthy subjects utilizing the high throughput method, Surface Enhanced Laser Desorption/Ionization (SELDI). We hypothesize that there is a unique set of proteins expressed in serum and urine in stone patients that can be detected by SELDI. Ultimately, this will better our understanding of stone disease and help develop new prevention strategies.
Urinary stone disease affects 10% of the Canadian population during their lifetime and
approximately half of these patients will have another episode within ten years. Currently,
patients undergo metabolic testing (serum and 24 hour urine tests) to identify modifiable
risk factors; however, no modifiable risk factors are identified in many patients, yet they
continue to form stones. New techniques must be developed to identify stone patients at risk
for future recurrences and ultimately to develop more specific prevention strategies.
Urinary protein levels are not routinely measured in stone patients while there is strong
evidence that proteins play a role in the etiology of stones. The purpose of this study is
to examine the urinary and serum proteins of stone formers compared to healthy subjects
utilizing the high throughput method, Surface Enhanced Laser Desorption/Ionization (SELDI).
We hypothesize that there is a unique set of proteins expressed in serum and urine in stone
patients that can be detected by SELDI. Once a protein is identified as a biomarker, a
specific assay similar to a quick and affordable dipstick test may be developed to identify
those stone patients at risk of future stones. Ultimately, this will better our
understanding of stone disease and help develop new prevention strategies.
Comparisons: protein profiles (serum/urine) of stone patients both during the presence of a
stone and 6 weeks after they have passed it. comparison of stone profiles of stone patients
with controls (non-forming stone patients).
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Observational Model: Case Control, Time Perspective: Prospective
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