Urinary Calculi Clinical Trial
Official title:
The Impact of Silent Ureteral Stone on Renal Function and Kidney Anatomy: a Prospective Analysis
Ureteral stones may be silent in 5.3% of patients. The goal of this study was to prospectively evaluate the impact of a silent ureteral stone on renal function.
The prevalence of nephrolithiasis is increasing worldwide, reaching 5.2% in North America
and 10.1% in Italy. The widespread use of computed tomography and ultrasonography have
resulted in a greater detection rate of asymptomatic stones and, in part, might explain the
trend. Clinically, kidney or ureteral stones range in severity from asymptomatic to
presenting with complete renal failure. Therefore, it is not only the alarming incidence of
urinary stone disease, but also the associated burden that makes this one of the most
concerning conditions in public health.
The situation becomes even more distressing when managing asymptomatic stones. Studies of
the natural history of stones have revealed that only 20% of patients yearly actually become
symptomatic from a new stone, and one half of those require surgical intervention at some
point. The guidelines are well established for the treatment of symptomatic urolithiasis,
and many investigators have extensively studied the management of silent kidney stones.
Conversely, the same is not true for silent ureterolithiasis. The purpose of the present
study is to report the investigators experience managing silent ureteral stones and to
prospectively analyze their true influence on renal function.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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