Radio-Immunotherapy Before Cystectomy in Locally Advanced Urothelial

Status Active, not recruiting

Clinical Trial Summary

A prospective, single arm, multicenter, Phase II-Trial to assess safety and efficacy of preoperative Radiation therapy before radical CystEctomy combined with ImmunoTherapy in locally advanced urothelial carcinoma of the bladder

Clinical Trial Description

Patients with locally advanced bladder cancer have a poor prognosis despite radical surgical therapy. The addition of perioperative combination chemotherapy did not add significant benefit to surgery alone. There is data indicating a synergistic effect of radiation and immunotherapy. Therefore, combined application of radiotherapy with Nivolumab before radical cystectomy might lead to improved cure rates and local control in this poor prognosis group with locally advanced bladder cancer. The aim of this phase-II study is to assess feasibility and safety of immunotherapy combined with neoadjuvant radiation before radical cystectomy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03529890
Study type	Interventional
Source	Technical University of Munich
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	February 4, 2019
Completion date	August 2023

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See also
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Radio-Immunotherapy Before Cystectomy in Locally Advanced Urothelial Carcinoma of the Bladder — RACE IT

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms