| Eligibility |
Inclusion Criteria:
(Items 1, 2, and 4 meet at the same time, and items 3 and 5 meet one of them)
1. Obtain the informed consent of the subjects before any trial-related activities
(including activities carried out to assess the eligibility of subjects);
2. Men or women over the age of 18 at the time of screening;
3. The diagnosis of hyperuricemia refers to the fasting of serum uric acid > 420umol/L (7
mg/dl) twice on different days under a normal purine diet.
4. The weight meets the following requirements (a or b): a) BMI = 25.0 kg/m2; b) waist
circumference, female = 85 cm, male = 90 cm.
5. Suffering from hyperuricemia and/or gout.-
Exclusion Criteria:
1. Use of drugs that may affect uric acid within 1 month before enrollment, including;
benzbromarone, allopurinol, febuxostat, etc.;
2. Abnormal liver function, ALT and AST are more than 2.5 times the upper limit of
normal;
3. Other diseases that affect glucose and lipid metabolism: hyperthyroidism,
hypothyroidism, hypercortisolism, etc.;
4. Diabetic patients with poor blood sugar control: HbA1c>7%;
5. Chronic kidney disease or severe renal impairment, according to eGFR grading
<45mL/min/1.73m2;
6. The life expectancy does not exceed 5 years;
7. Female subjects who are pregnant or plan to become pregnant within the next 24 weeks;
8. Those who are expected to be unable to complete the intervention follow-up in other
circumstances;
9. If other drugs are used in combination, the drug dose should be kept stable for three
months before enrollment;
10. Participated in other clinical trials within the past 4 weeks;
11. Use of drugs that affect body weight within 3 months before screening, including:
systemic steroids (intravenous, oral or intra-articular), tricyclic antidepressants,
psychiatric drugs or sedatives (eg, imipramine, amitriptyline, mirtazapine,
paroxetine, phenelzine, chlorpromazine, thioridazine, clozapine, olanzapine, valproic
acid, valproic acid derivatives, lithium salt), etc.;
12. Obesity caused by secondary diseases or drugs, including: elevated cortisol hormone
(for example: Cushing's syndrome), obesity caused by pituitary and hypothalamus
damage, obesity caused by reduction/discontinuation of weight loss drugs, etc.;
13. Inability to complete the exercise and for other reasons, the researcher believes that
it is not suitable to participate in this researcher.-
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