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Urge Urinary Incontinence clinical trials

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NCT ID: NCT04525105 Completed - Clinical trials for Pelvic Organ Prolapse

SMAD2, SMAD3 AND TGF-β GENE EXPRESSION IN URGE URINARY INCONTINENCE

Start date: November 1, 2017
Phase:
Study type: Observational

Urge urinary incontinence (UUI) is a common health problem. Changes in collagen metabolism in pelvic support organs, such as uterosacral ligaments (USLs), might be responsible for the complex pathophysiology of UUI. The TGF-β pathway is involved in collagen synthesis and degradation. The Transforming Growth Family- β (TGF-β) superfamily has essential intracellular signaling components, such as newly identified SMAD family members. We evaluated the changes in the levels of TGF-β and SMAD gene and protein expression in the USL of patients with concomitant pelvic organ prolapse (POP) and UUI.

NCT ID: NCT03923348 Terminated - Overactive Bladder Clinical Trials

Pelvic Floor Muscle Training With Leva System for Urge Incontinence

Start date: June 6, 2019
Phase: N/A
Study type: Interventional

This is a pilot non-comparative study to assess the effectiveness of pelvic floor muscle training guided by the leva® system for improving change in subject-reported incontinence-related quality of life and urgency urinary incontinence (UUI) episode frequency based on voiding diaries in women at 8 weeks.

NCT ID: NCT02311634 Completed - Clinical trials for Urge Urinary Incontinence

A Comparison of Electrical Pudendal Nerve Stimulation and Transvaginal Electrical Stimulation for Urge Incontinence

Start date: December 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether electrical pudendal nerve stimulation is more effective than transvaginal electrical stimulation in treating urge urinary incontinence (UUI).

NCT ID: NCT02129816 Terminated - Overactive Bladder Clinical Trials

Bryophyllum Pinnatum Versus Solifenacin Versus Placebo for Overactive Bladder

BryoSoliP
Start date: May 2014
Phase: Phase 2/Phase 3
Study type: Interventional

Overactive bladder (OAB) is an enigmatic condition that is treated symptomatically with anticholinergic drugs (gold standard 2013). In a clinical pilot study was found to be a trend for a higher reduction of the micturition frequency in the Bryophyllum pinnatum group - treated with chewing tablets containing 50% of dried BP leaf press juice - than in the placebo group (n=20, p=0.064) Hypothesis: To test the superior effectivity of Bryophyllum versus Placebo in the treatment of OAB with the needed number (Purpose 1) and to assess in an experimental arm the side effects of BP in comparison to the standard drug (Vesicare) in a clincial trial (Purpose 2).

NCT ID: NCT01940367 Enrolling by invitation - Overactive Bladder Clinical Trials

Electrical Nerve Stimulation for Overactive Bladder a Comparison of Treatments

Start date: October 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether transcutaneous sacral nerve stimulation (TENS SNS) versus percutaneous tibial nerve stimulation (PTNS) is a more effective therapeutic option for subjects with idiopathic overactive bladder (OAB) who have failed conventional therapy. Our primary hypothesis is that TENS therapy is a more effective treatment option due to ease of use and improved subject compliance with this form of therapy.

NCT ID: NCT01786967 Completed - Clinical trials for Urge Urinary Incontinence

Understanding the Response to Fesoterodine Through Genetic Evaluation in the Elderly (URGE)

URGE
Start date: September 2012
Phase: Phase 3
Study type: Interventional

Urge urinary incontinence, characterized by unpredictable and embarrassing large volume urine leakage, is a major health issue for elderly women, as it is incredibly common and significantly impairs quality of life. Although anticholinergic medications are the most common therapy, the investigators are unable to predict an individual's response to a particular drug in terms of both effectiveness and side effects. Through genetic evaluation, the investigators have the potential to personalize and optimize drug therapy for millions of elderly women suffering from urge incontinence.

NCT ID: NCT01737411 Recruiting - Clinical trials for Urge Urinary Incontinence

Surgical vs. Medical Treatment of Urge Urinary Incontinence in Women

URGE-I
Start date: January 2013
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine if pelvic surgery can improve urge urinary incontinence in women more than standard medical treatment.

NCT ID: NCT01672190 Completed - Clinical trials for Urinary Incontinence

Lessening Incontinence by Learning Yoga

LILY
Start date: August 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the feasibility of recruiting women with urinary incontinence into a randomized controlled trial of a yoga therapy program.

NCT ID: NCT01619995 Completed - Clinical trials for Urge Urinary Incontinence

Brain Imaging Plus Urodynamics to Investigate the Brain's Control of the Bladder

NIRS/fBFB
Start date: August 2011
Phase: N/A
Study type: Observational

The goal of this project is to evaluate the applicability of non-invasive optical imaging for the measurement of brain function during investigation of the lower urinary tract.

NCT ID: NCT01559389 Completed - Clinical trials for Urge Urinary Incontinence

Incontinence & Intimate Partners: Assessing the Contribution of Treatment

IIMPACT
Start date: March 9, 2012
Phase: Phase 4
Study type: Interventional

Urge urinary incontinence (UUI) is a socially debilitating disease due to its inherently unpredictable nature and sometimes large volumes of urine loss. Women with UUI may experience anxiety over public episodes of incontinence and concerns about odor and, as a result, isolate themselves socially. This isolation affects both partners in the relationship and may be a source of discord. The impact of UUI also moves into personal relationships where fears or actual episodes of incontinence during physical intimacy, including but limited to intercourse, may result in limited interactions and changes in the relationship satisfaction for both partners. Few studies have examined the role of urinary incontinence, particularly UUI, in the dynamics of an intimate partner relationship and none have evaluated the impact of successful UUI treatment. The long-term goal of our research is to understand the social and emotional impact of pelvic floor disorders, particularly UUI, on the well-being of an intimate relationship. Ultimately, we aim to evaluate the role that successful treatment plays in the alleviation of discord in intimate partner relationships that are affected by UUI and other pelvic floor disorders. Our objective for this proposal is to characterize, using validated, quantifiable methods the quality of the relationship in couples affected by UUI and to identify the role that treatment plays in improving this relationship. Our central hypothesis is that UUI has a negative impact upon the emotional and physical well-being of a relationship and that effective treatment will result in improvement in areas of the relationship that have been detrimentally affected by UUI. Our rationale for this study is that an understanding of UUI in the context of a couple, particularly from the perspective of the male partner, will improve our ability to holistically treat UUI, thus improving patient outcomes and satisfaction.