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Urethral Stricture clinical trials

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NCT ID: NCT03973619 Completed - Urethral Stricture Clinical Trials

Urethral Stricture: A Comparison Between Jugal or Labial Graft Urethroplasty

Start date: October 1, 2016
Phase: N/A
Study type: Interventional

Buccal mucosa urethroplasty is a current fashion in urethral stricture management. In our university centre (Hospital de Clínicas de Porto Alegre) is a common surgical treatment choice. This paper aims to evaluate the success rate of this treatment after randomized choice between labial and jugal (inner cheek) grafts during the past two years.

NCT ID: NCT03859024 Completed - Pain, Postoperative Clinical Trials

Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty

Start date: March 22, 2019
Phase: Phase 4
Study type: Interventional

The investigator's study aims to see if an enhanced recovery regimen of pain medications before and during surgery will decrease the use and risk of opioid pain medications as well as improve pain control in anterior urethroplasty patients. Participants will be randomized to one of two pain regimens (enhanced recovery regimen vs standard regimen).

NCT ID: NCT03851952 Withdrawn - Clinical trials for Lower Urinary Tract Symptoms

Re-Establishing Flow Via Drug Coated Balloon for the Treatment of Urethral Stricture Disease - Registry Study

ROBUST IV
Start date: May 31, 2019
Phase: N/A
Study type: Interventional

The ROBUST IV study is designed to collect and better understand "real-world" outcomes for men undergoing urethral dilation using the Optilume Drug Coated Balloon (DCB) for treatment of urethral stricture.

NCT ID: NCT03720223 Completed - Urethral Stricture Clinical Trials

Liposomal Bupivacaine To Control Post-Operative Pain Following BMG

Start date: January 20, 2015
Phase: Phase 3
Study type: Interventional

This is a single blinded-randomized controlled trial that recruit male patients for substitution urethroplasty using buccal mucosal graft. The study investigators aim to assess the efficacy and safety of liposomal bupivacaine injection to the buccal graft harvest site on post-operative main score, morphine equivalence requirement and oral morbidities.

NCT ID: NCT03572348 Completed - Surgery Clinical Trials

VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures.

VeSpAR
Start date: September 26, 2018
Phase: N/A
Study type: Interventional

The investigators want to verify whether the surgical outcome of vessel-sparing anastomotic repair in isolated short bulbar urethral strictures is not inferior to the surgical outcome of transecting anastomotic repair. Furthermore, the investigators compare the functional outcome of both techniques verifying if there is less erectile dysfunction after vessel-sparing anastomotic repair than after transecting anastomotic repair.

NCT ID: NCT03499964 Active, not recruiting - Urethral Stricture Clinical Trials

ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease

ROBUST-III
Start date: June 22, 2018
Phase: N/A
Study type: Interventional

ROBUST III is a prospective, multi-center, randomized controlled adaptive sample size clinical trial to establish the safety and effectiveness for the Optilume Stricture Drug Coated Balloon (DCB).

NCT ID: NCT03270384 Active, not recruiting - Urethral Stricture Clinical Trials

Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease

ROBUST-II
Start date: October 25, 2017
Phase: N/A
Study type: Interventional

The study described below is designed to assess the safety and device performance for the drug coated balloon (DCB) for the treatment of urethral stricture.

NCT ID: NCT03258658 Not yet recruiting - Urologic Diseases Clinical Trials

Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures

Start date: October 2024
Phase: Phase 1
Study type: Interventional

This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males. The proposed study design is a prospective non-randomized and uncontrolled single-center investigation. Autologous urothelial cells (UCs) and smooth muscle cells (SMCs), obtained from enrolled male subjects' bladder tissue samples, will be culture expanded in vitro and used to seed tubular PGA scaffolds to create autologous urethral constructs for the repair of urethral strictures.

NCT ID: NCT03205670 Enrolling by invitation - Urethral Stricture Clinical Trials

Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers

Start date: June 1, 2017
Phase: Early Phase 1
Study type: Interventional

This study investigates safety and efficacy of surgical treatment of patients with anterior urethral stricture using a tissue-engineered construct based on autologous buccal mucosa cells and matrix from reconstituted collagen and reinforcing polylactoglycolide fibers. This is a single arm study with no control. Success will be assessed via objective and subjective methods; complications will be tallied in a standardized fashion. Outcomes will be measured at five years.

NCT ID: NCT03061344 Not yet recruiting - Urethral Stricture Clinical Trials

Liquid Buccal Mucosa Graft Urethroplasty

LBMG
Start date: February 2017
Phase: Phase 1
Study type: Interventional

Study Objectives The current definitive treatment options for urethral stricture disease include endoscopic urethrotomy known as Direct Vision Internal Urethrotomy (DVIU) or open reconstruction known as urethroplasty (1-6). The purpose of this study is to determine feasibility of endoscopic-only repair of urethral stricture or bladder neck contracture using a combination of existing surgical techniques of internal urethrotomy (or bladder neck incision) augmented by buccal mucosal graft.