Uremia Clinical Trial
Official title:
A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, CROSS-OVER STUDY TO EVALUATE THE RENAL AND BIOHUMORAL EFFECTS OF L-CYSTEINE COMPARED TO PLACEBO IN STABLE PERITONEAL DIALYSIS PATIENTS WITH RESIDUAL DIURESIS
Over the last decades, peritoneal dialysis has grown worldwide to become one of the most common modalities of renal replacement therapy, particularly in developing or newly industrialized countries, such as India, China, Korea, Turkey, Malaysia, Mexico and Brazil. Peritoneal dialysis has been associated with an initial survival benefit compared to hemodialysis, although this advantage becomes less apparent over time, likely due to the progressive loss of residual renal function and the development of pathological alterations of peritoneum . Recent results suggest that an antioxidant therapy by N-acetyl-cysteine oral supplementation may improve residual renal function in peritoneal dialysis patients. This finding may have major clinical relevance, as preserving residual renal function in peritoneal dialysis patients has been associated with improved survival . Aim of the present randomized, double-blind, crossover study is to confirm the preliminary evidence of the beneficial effects of antioxidant agents on residual renal function by using the L-enantiomeric form of cysteine in 10 prevalent peritoneal dialysis patients with residual diuresis.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Supportive Care
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT00577967 -
Gabapentin - A Solution to Uremic Pruritus?
|
N/A | |
Completed |
NCT01583309 -
Effects of Convective Therapies in Dialysis Patients
|
Phase 3 | |
Completed |
NCT03437538 -
Reduction Ratio and Clearance During Hemodialysis With MCO-filter Compared to HDF With Standard High-flux Filter
|
N/A | |
Completed |
NCT00649298 -
A Clinical Trial of IntensiVE Dialysis
|
Phase 4 | |
Completed |
NCT05750875 -
Gabapentin Versus Loratadine in Uremic Pruritus
|
Phase 4 | |
Recruiting |
NCT01408797 -
Clonal Deletion on Living-Relative Donor Kidney Transplantation
|
Phase 1/Phase 2 | |
Completed |
NCT01267760 -
Clinical and Biochemical Effects of Multipass Hemodialysis
|
Phase 2 | |
Recruiting |
NCT00375635 -
Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis
|
N/A | |
Recruiting |
NCT05076318 -
Dysregulated Urea-synthesis at Terminal Uremia
|
N/A | |
Completed |
NCT05899283 -
A Comparative Study of Two Kinds of Hemodialysis Filters
|
N/A | |
Completed |
NCT04768309 -
Impact of Intestinal Microbiota on Uremic Toxins Productions
|
N/A | |
Not yet recruiting |
NCT05386433 -
Paxlovid in the Treatment of COVID-19 Patients With Uremia
|
Early Phase 1 | |
Completed |
NCT01391884 -
Elimination of Incretin Hormones in Patients With Severe Kidney Failure
|
N/A | |
Completed |
NCT00442819 -
Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney
|
Phase 4 | |
Not yet recruiting |
NCT02266238 -
Stenosis of Arteria-Venous Fistula in Maintenance Hemodialysis Patients: Early Intervention Trial
|
N/A | |
Recruiting |
NCT01766895 -
Long-term Follow Up of Viral Hepatitis in Uremic Patients in Taiwan
|
||
Completed |
NCT00388648 -
Very Low Protein Diet or Dialysis in Uremic Elderly?
|
Phase 4 | |
Withdrawn |
NCT03416192 -
12 Weeks of Hemodialysis With Medium Cut-Off Filter Compared to Hemodiafiltration With Standard High-flux Filter.
|
N/A | |
Recruiting |
NCT02606955 -
Probing the Dry Weight by Bioimpedance: The Resistance Stabilization Test
|
N/A | |
Recruiting |
NCT02446535 -
Probing the Dry Weight (DW) by Bioimpedance (BIA): Which is the Gold Standard Between Clinical DW and BIA DW?
|
N/A |