Uremia Clinical Trial
Official title:
Probing the Dry Weight (DW) by Bioimpedance (BIA): Which is the Gold Standard Between Clinical DW and BIA DW?
Clinical methods are fundamental in probing the DW. They must be supported by strict BIA protocols. REST appears to be a (the) brilliant solution in solving the old problem of DW in HD patients
Probing the dry weight (DW) was largely dependent on clinical subjective estimates until
recently. New bedside non-invasive tools have been developed with the aim of providing more
objective information on volume status and guiding physicians in the quest for DW. Among
them, bioimpedance (BIA) appears to be very promising.
Very recently, a BIA test aimed at assessing DW in hemodialysis (HD) patients has been
developed, the "REsistance Stabilization Test" (REST). It is called BIA DW. Its rationale is
based on the achievement of the flattening of the curve of the ratio R0/Rt (R0 is resistance
at time 0 and Rt is resistance at a given time t during the HD session) of less than + 1%
over 20 minutes in the presence of ongoing ultrafiltration.
Study protocol: the Clinical DW is the gold standard by definition. It is determined under
strict clinical surveillance by the same attending physician. She/he will be helped by a
clinical score of volume state about symptoms and signs of hypo- or hypervolemia. Then, this
Clinical DW will be compared with BIA DW, as obtained after performing REST
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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