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Clinical Trial Summary

RATIONALE: New ways to find out about hearing loss after treatment with chemotherapy may improve the ability to plan cancer treatment and may help patients live more comfortably.

PURPOSE: This clinical trial is assessing ear damage in young cancer patients treated with cisplatin.


Clinical Trial Description

OBJECTIVES:

- Determine the optimal criteria for determination of ototoxicity in younger cancer patients treated with cisplatin.

- Determine the feasibility of including ultrahigh frequency and evoked otoacoustic emission testing as adjunctive measures of ototoxicity.

- Determine the feasibility and necessity of central review of audiometry data.

OUTLINE: This is a multicenter, prospective, cohort study.

Patients undergo hearing tests (conventional, otoscopy, ultrahigh frequency, and otoacoustic emission testing) before the first course of planned cisplatin, before each subsequent course of cisplatin, and 4 weeks after the last dose of cisplatin.

Patients who are scheduled to receive hematopoietic progenitor stem cell transplantation undergo hearing tests before the transplantation and 4 weeks after transplantation.

PROJECTED ACCRUAL: A total of 282 patients will be accrued for this study. ;


Study Design


Related Conditions & MeSH terms

  • Ototoxicity
  • Unspecified Childhood Solid Tumor, Protocol Specific

NCT number NCT00458887
Study type Observational
Source Children's Oncology Group
Contact
Status Completed
Phase N/A
Start date May 2007
Completion date February 28, 2017

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