Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial
Official title:
Regenecare® in the Treatment of Skin Rash Associated With Cetuximab (Erbitux®) or Other EGFR Treated Cancer Patients
RATIONALE: Regenecare® wound gel may help relieve pain and itching in patients who develop
an acne-like rash while undergoing treatment with cetuximab or another epidermal growth
factor receptor inhibitor for cancer.
PURPOSE: This clinical trial is studying how well Regenecare® wound gel works in treating
rash in patients receiving cetuximab or another epidermal growth factor receptor inhibitor
therapy for cancer.
OBJECTIVES:
Primary
- Determine the efficacy of Regenecare® wound gel in alleviating pain and itching in
patients who develop an acneiform rash while undergoing treatment with cetuximab or
other EGFR inhibitor therapy for cancer.
Secondary
- Determine the efficacy of this drug in reducing the severity of rash in these patients.
- Determine the efficacy of this drug in reducing the redness and appearance of the rash
in these patients.
- Determine the tolerability of this drug in these patients.
OUTLINE: This is a prospective study.
- Observation: Patients undergo evaluation by full-face photography prior to development
of skin rash (baseline). While undergoing concurrent cancer therapy, patients
self-monitor for the appearance of an acneiform rash. Upon initial onset of rash,
patients proceed to treatment.
- Treatment: Patients apply topical Regenecare® wound gel to the face ≥ 4 times daily.
Treatment continues for 4 weeks in the absence of unacceptable toxicity.
Patients are evaluated weekly by facial examination, full-face photography, and patient
satisfaction questionnaires.
;
Primary Purpose: Supportive Care
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