Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial
Official title:
Characterization of Chemotherapy/Biotherapy-Induced Peripheral Neuropathy: Refinement of Clinical Measures
RATIONALE: Learning about the effects of chemotherapy and biological therapy on nerve
function may help doctors plan treatment and help patients live more comfortably.
PURPOSE: This clinical trial is studying peripheral neuropathy in patients who are receiving
chemotherapy or biological therapy for cancer.
OBJECTIVES:
- Determine the change in peripheral nerve function in cancer patients during and after
treatment with chemotherapy or biologic therapy.
- Determine the clinical measurement of hearing-related air and bone conduction and
vibratory sensation in these patients.
- Correlate the changes in orthostatic blood pressure using both the Vasotrac automated
blood pressure device and the standard clinical automated blood pressure equipment.
- Determine the patient's perception of hearing quality before and after treatment with
chemotherapy or biologic therapy.
OUTLINE: This is a multicenter study.
Patients undergo a 1-hour peripheral nerve function assessment, including hearing, vibratory
sensation, and blood pressure testing, at baseline and then at 4, 8, and 12 weeks during
treatment with chemotherapy or biologic therapy.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
;
Observational Model: Cohort, Time Perspective: Prospective
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